JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (5): 45-49.doi: 10.6040/j.issn.1671-7554.0.2016.020

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Expression and significance of ER and PR in fibroids and myometrium during pregnancy

LIU Ran1, TAO Guowei2, ZHEN Junhui3, LUO Xia1, QIAN Richeng4   

  1. 1. Department of Obstetrics and Gynecology;
    2. Department of Ultrasonography;
    3. Department of Pathology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    4. State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, Jiangsu, China
  • Received:2016-01-06 Online:2016-05-16 Published:2016-05-16

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Abstract: Objective To explore the expression and significance of ER and PR in fibroids and myometrium during pregnancy. Methods (1) We collected 9 pregnant womens fibroids(group A)and myometrium(group B), and 12 non-pregnant womens fibroids(group C)and myometrium(group D). The expressions of ER and PR in these tissues were detected with immunohistochemistry. (2) We selected 110 pregnant women with fibroids as the research objects, and recorded the sizes of fibroids through ultrasonic reports in early pregnancy(less than 13 weeks), mid pregnancy(16 to 23 weeks gestation)and late pregnancy(37 to 40 weeks gestation). Results (1) The expressions of ER in group A and B were negative. The expression of PR in group A was significantly higher than that in group B(P=0.033). The expressions of ER and PR in group A were significantly lower than those in group C(P=0.000, P=0.001). (2) There was no significant difference in the sizes of fibroids between early mid and late pregnancy(P=0.741). But fibroids had an 山 东 大 学 学 报 (医 学 版)54卷5期 -刘冉,等.ER、PR在妊娠期子宫肌瘤组织中的表达及意义 \=-increasing trend in early and mid pregnancy and had a decreasing trend in late pregnancy. Conclusion ER and PR may play an important role in the growth of fibroids during pregnancy. However, whether ER deletion is related to the slow growth of fibroids with high estrogen and progesterone during pregnancy still remains unclear.

Key words: Progesterone receptor, Pregnancy, Uterine fibroids, Estrogen receptor

CLC Number: 

  • R714.2
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