JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (5): 34-38.doi: 10.6040/j.issn.1671-7554.0.2015.053

Previous Articles     Next Articles

Estimation of reference range for thyroid functional parameter in pregnant women of Jinan City, China

SHEN Yan1, ZUO Changting2   

  1. 1. Department of Obstetrical, Shandong Maternal and Child Health Hospital, Jinan 250021, Shandong, China;
    2. Department of Obstetrical, Shandong Provincial Hospital Affilicated to Shandong University, Jinan 250021, Shandong, China
  • Received:2015-01-14 Online:2016-05-16 Published:2016-05-16

PDF (PC)

2353

Abstract: Objective To establish the refernce ranges for specific serum FT3, FT4 and TSH in different stages of the pregnant women of Jinan City, China. Methods A total of 370 pregnancy women were chosen as the study group, and 60 non-pregnancy women were chosen as the control group. According to the guidelines of United States National Institute of Clinical Biochemical(NACB), the serum levels of TSH, FT4, FT3, thyroglobulin antibody(TgAb), thyroid peroxidase antibody(TPOAb), thyrotrophin receptor antibody(TRAb)were detected by electrochemiluminescence method. Results The reference ranges of the serum levels of FT3, FT4 and TSH during the early, medium, and late periods were 3.33-5.78, 3.07-5.52, 2.91-5.46 pmol/L; 12.60-18.94, 8.74-17.23, 8.64-17.21 pmol/L; and 0.27- 4.27, 0.53- 4.75, 0.76- 4.59 mIU/L. Conclusion The reference ranges of the serum levels of FT3, FT4 and TSH at the different gestation stages in Jinan City have a large difference between the pregnant women of the other areas, and also have a large difference of the reference ranges of the pregnant women recommended by ATA.

Key words: Thyroid stimulating hormone, Thyroxine, Reference range, Pregnancy

CLC Number: 

  • R714.5
[1] Granfors M, Akerud H, Skogo J, et al. Targeted thyroid testing during pregnancy in clinical practice[J]. Obstet Gynecol, 2014, 124(1): 10-15.
[2] Pappa T, Ferrara AM, Refetoff S, et al. Inherited defects of thyroxine-binding proteins[J]. Best Pract Res Clin Endocrinol Metab, 2015, 29(5): 735-747.
[3] Donnay S, Arena J, Lucas A, et al. Iodine supplementation during pregnancy and lactation. Position statement of the working group on disorders related to iodine deficiency and thyroid dysfunction of the Spanish Society of Endocrinology and Nutrition[J]. Endocrinol Nutr, 2014, 61(1): 27-34.
[4] Tortosa F. Subclinical thyroid dysfunction in pregnancy[J]. Endocrinol Nutr, 2011, 58(6): 255-257.
[5] Forbes S. Pregnancy sickness and parent-offspring conflict over thyroid function[J]. Theor Biol, 2014, 21; 355: 61-67.
[6] Wang S, Teng WP, Li JX, et al. Effects of maternal subclinical hypothyroidism on obstetrical outcomes during early pregnancy[J]. Endocrinol Invest, 2012, 35(3): 322-325.
[7] Mannisto T, Vaarasmaki M, Pouta A, et al. Thyroid dysfunction and autoantibodies during pregnancy as predictive factors of pregnancy complications and maternal morbidity in later life[J]. Clin Endocrinol Metab, 2010, 95(3): 1084-1094.
[8] Surks MI, Boucai L. Age- and race-based serum thyrotropin reference limits[J]. Clin Endocrinol Metab, 2010, 95(2): 496-502.
[9] Yue B, Rockwood AL, Sandrock T, et al. Free thyroid hormones in serum by direct equilibrium dialysis and online solid-phase extraction-liquid chromatography/tandem mass spectrometry[J]. Clin Chem, 2008, 54(4): 642-651.
[10] Benhadi N, Wiersinga WM, Reitsma JB, et al. Higher maternal TSH levels in pregnancy are associated with increased risk for miscarriage, fetal or neonatal death[J]. Eur J Endocrinol, 2009, 160(6): 985-991.
[11] Wang S, Teng WP, Li JX, et al. Effects of maternal subclinical hypothyroidism on obstetrical outcomes during early pregnancy[J]. Endocrinol Invest, 2012, 35(3): 322-325.
[12] Luetic AT, Miskovic B. Is hyperthyroidism underestimated in pregnancy and misdiagnosed as hyperemesis gravidarum?[J]. Med Hypotheses, 2010, 75(4): 383-386.
[13] Laurberg P, Bournaud C, Karmisholt J, et al. Management of Graves’ hyperthyroidism in pregnancy: focus on both maternal and foetal thyroid function, and caution against surgical thyroidectomy in pregnancy[J]. Endocrinol, 2009, 160(1): 1-8.
[14] Moleti M, Lo Presti VP, Campolo MC, et al. Iodine prophylaxis using iodized salt and risk of maternal thyroid failure in conditions of mild iodine deficiency[J]. Clin Endocrinol Metab, 2008, 93(7): 2616-2621.
[15] Lambert-Messerlian G, McClain M, Haddow JE, et al. First- and second-trimester thyroid hormone reference data in pregnant women: a FaSTER(First- and second-trimester evaluation of risk for aneuploidy)research consortium study[J]. Obstet Gynecol, 2008, 199(1): 62.e1-62.e6.
[16] Gong Y, Hoffiman BR. Free thyroxine reference interval in each trimester of pregnancy determined with the Roche Modular E-170 electrochemiluminescent immunoassay[J]. Clin Biochem, 2008, 41(10-11): 902-906.
[17] 李佳, 滕卫平, 单忠艳, 等. 中国汉族碘适量地区妊娠月份特异性TSH和T4的正常参考范围[J]. 中华内分泌代谢杂志,2008, 24(6): 605-608. LI Jia, TENG Weiping, SHAN Zhongyan, et al. Gestational month-specific reference ranges for TSH and thyroxine in Han nationality women in iodine sufficient area of China[J]. Chinese Journal of Endocrinology And Metabolism, 2008 24(6): 605-608.
[18] 罗军,韩密,宋梦帆,等.两种免疫试剂检测妊娠期甲状腺功能结果的比较[J].中华围产医学杂志, 2012, 15(7): 404-410. LUO Jun, HAN Mi, SONG Mengfan, et al. Comparison of thyroid function tests results determined by two kinds of immunoassay in uncomplicated pregnant women[J]. Chinese Journal of Perinatal Medicine, 2012, 15(7): 404-410.
[19] 薛海波,李元宾,滕卫平,等. 妊娠早期母亲亚临床甲状腺功能减退症对其后代脑发育影响的前瞻性研究[J]. 中华内分泌代谢杂志,2010, 26(11): 135-137. XUE Haibo, LI Yuanbin, TENG Weiping, et al. Impact of maternal subclinical hypothyroidism during the first trimester on brain development of the offspring: a prospective study[J]. Chinese Journal of Endocrinology And Metabolism, 2010, 26(11): 135-137.
[20] Yu QY, Dong ZL, Dong L, et al. Trimester- and method-specific reference intervals for thyroid tests in pregnant chinese women: methodology, euthyroid definition and iodine status can influence the setting of reference intervals[J]. Clin Endocrinol(Oxf), 2011, 74(2): 262-269.
[21] Boucai L, Surks MI. Reference limits of serum TSH and free T4 are significantly influenced by race and age in an urban outpatient medical practice[J]. Clin Endocrinol(Oxf), 2009, 70(5): 788-793.
[22] Moradi S, Gohari MR, Aghili R. Thyroid function in pregnant women: iodine deficiency after iodine enrichment program[J]. Gynecol Endocrinol, 2013, 29(6): 596-599.
[23] 金行一,朱素娟,徐卫民,等.碘适量地区城市妊娠妇女亚临床甲状腺功能异常情况的研究[J]. 中国预防医学杂志, 2010,1(11):2-3. JIN Xingyi, ZHU Sujuan, XU Weimin, et al. Study on subclinical abnormalities of thyroid function in pregnant women in iodine sufficient areas[J]. Chinese Preventive Medicine, 2010, 1(11):2-3.
[1] ZHOU Chaoxiong, FU Yi. Prediction of aggression behavior in bipolar disorder patients by thyroid hormone and cortisol levels [J]. Journal of Shandong University (Health Sciences), 2026, 64(1): 37-42.
[2] HAN Xinwei, NIU Yue, WEI Daimin. Influence of the duration of estrogen treatment prior to frozen embryo transfer in hormone replacement protocols in endometrial preparation on neonatal birth weight [J]. Journal of Shandong University (Health Sciences), 2025, 63(11): 46-52.
[3] WANG Rui, YU Kang, LIU Yanping. Research advances in Vitamin K2 and pregnancy-related diseases [J]. Journal of Shandong University (Health Sciences), 2024, 62(8): 9-17.
[4] DU Juan, LI Xiufang, LI Yuanmei, WANG Huidan. Effect of Yunkang granule on pregnancy outcome of frozen-thawed embryo transfer [J]. Journal of Shandong University (Health Sciences), 2024, 62(7): 84-90.
[5] LIN Yuyang, WANG Bei, LI Fei. Prediction of lateral lymph node metastasis in papillary thyroid carcinoma larger than 10 mm [J]. Journal of Shandong University (Health Sciences), 2024, 62(6): 54-64.
[6] CAO Danfeng, LI Hui. Influence of adverse childhood experiences on depression in pregnancy: mediating effect of maternal-fetal attachment [J]. Journal of Shandong University (Health Sciences), 2024, 62(3): 87-91.
[7] ZHAO Shengrui, QU Huiling, XU Xinxin, ZHANG Fangfang, YAN Lei. Comparison of medical abortion and surgical abortion in the management of missed abortion after in vitro fertilization/intracytoplasmic sperm injection-embryo transfer [J]. Journal of Shandong University (Health Sciences), 2024, 62(2): 69-74.
[8] LI Junxiu, YUAN Yingying, HUANG Lingyan, ZHAO Junli. Clinical value of CD38 expression in endometrium for anti-inflammatory therapy before embryo transfer [J]. Journal of Shandong University (Health Sciences), 2023, 61(8): 54-60.
[9] XU Yueming, ZHANG Jie, JIANG Lei, YIN Li, ZHAO Pan, XU Xin, HAO Guimin. Relationship between the number of retrieved oocytes and IVF outcomes correlated with elevated progesterone on hCG day [J]. Journal of Shandong University (Health Sciences), 2023, 61(5): 44-50.
[10] Writing experts: BAN Yanli, ZHAO Ying, LI Hua, LIU Wei, RONG Fengnian, ZHAO Shuping, CUI Baoxia. Expert consensus of practical clinical classification system with optimal surgical strategy for cesarean scar pregnancy [J]. Journal of Shandong University (Health Sciences), 2023, 61(11): 1-10.
[11] SONG Min, CAO Luquan, WU Lilong, WU Shuxia, LIU Jing, ZHANG Juan, LIU Cuiying. Clinical analysis of 9 cases with group A streptococcus infection in obstetrics [J]. Journal of Shandong University (Health Sciences), 2023, 61(11): 89-95.
[12] ZHANG Lixia, TIAN Yizheng, LYU Shangge, ZHANG Yanan, YAN Lei. Effects of GnRH-a pretreatment on the pregnancy outcomes of frozen embryo transplantation in patients with endometriosis [J]. Journal of Shandong University (Health Sciences), 2023, 61(10): 63-68.
[13] CI Qianqian, WU Shengying, WAN Qiuhua, MA Yunrong, ZHAO Jianwen, ZHANG Jian. Analysis of prenatal screening and diagnostic methods in 10,265 cases of advanced maternal age [J]. Journal of Shandong University (Health Sciences), 2023, 61(1): 51-57.
[14] ZHANG Hongyuan, GU Yongzhong. Vaginal delivery after myomectomy in the first trimester of pregnancy: a case report and literature review [J]. Journal of Shandong University (Health Sciences), 2023, 61(1): 69-73.
[15] LU Qun, ZHAO Lulu. Progress on assisted reproductive technology for women with atypical endometrial hyperplasia and endometrial carcinoma receiving fertilitysparing treatment [J]. Journal of Shandong University (Health Sciences), 2022, 60(9): 35-41.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd