JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (3): 81-86.doi: 10.6040/j.issn.1671-7554.0.2015.263

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Comparative study of gemstone spectral CT and conventional ultrasound spectroscopy for the diagnosis of benign and malignant thyroid nodules

LI Jinye1, SONG Gesheng2, SONG Jiqing3, WANG Dawei2, JIN Xianwen4, ZHANG Chengqi2   

  1. 1. School of Medicine, Shandong University, Jinan 250012, Shandong, China;
    2. Department of Medical Imaging, Qianfoshan Hospital Affilicated to Shandong University, Jinan 250014, Shandong, China;
    3. Department of Medical Imaging, Shandong Provincial Hospital Affilicated to Shandong University, Jinan 250021, Shandong, China;
    4. College of Radiology, Taishan Medical College, Taian 271016, Shandong, China
  • Received:2015-03-11 Online:2016-03-10 Published:2016-03-10

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Abstract: Objective To explore the value of the gemstone spectral CT imaging in differential diagnosis of benign and malignant thyroid nodules,and compare its diagnostic value with ultrasonography. Methods Forty-four thyroid nodules were analyzed retrospectively. All patients underwent gemstone spectral CT scanning, arterial phase enhanced CT imaging and ultrasonography. According to the pathology results, nodules were divided into benign group and malignant group. Data of spectral CT imaging and ultrasonography were analyzed by independent sample t test or nonparametric test and multivariate Logistic regression analysis respectively. The optimal iodine concentration threshold to predict malignancy was obtained by receiver operating characteristic(ROC)curve, and the sensitivity and specificity were achieved. Results A total of 44 nodules were detected, including 23 benign and 21 malignant nodules. Between the two groups, there was difference of the average iodine concentration, standardized iodine concentration, and slope of spectral curve in non-contrast CT imaging(P<0.05), while there was no difference in the arterial phase(P>0.05). The optimal iodine concentration to predict malignancy was 0.32×100 μg/mL in non-enhanced phase with 100% sensitivity and 79.5%specificity. The nodules form, border, cystic situation between the two groups were statistically different in ultrasonography with multivariate logistic regression analysis(P<0.05). The sensitivity and specificity was 山 东 大 学 学 报 (医 学 版)54卷3期 -李进叶,等.宝石能谱CT与常规超声对甲状腺结节良恶性诊断价值的对照分析 \=-84.2% and 68.1%, respectively. Conclusion Gemstone spectral CT imaging in non-contrast phase has potential value in diagnosis of benign and malignant thyroid nodules, and is better than that of ultrasonic in diagnosis of the nodules whose diameter great than or equal to 1 cm.

Key words: Thyroid nodule, Ultrasonography, Gemstone spectral CT, Differential diagnosis

CLC Number: 

  • R445.3
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