Abstract: Objective To evaluate the clinical significance of serum miR-375 in the diagnosis and postoperative monitoring of cervical cancer by analyzing its expression in cervical intraepithelial neoplasia(CIN)and cervical cancer. Methods A total of 178 subjects, including 64 patients with cervical cancer, 64 patients with CIN and 50 healthy controls, were enrolled in the study. The expressions of serum miR-375 and CA125 were measured, and their diagnostic significance was evaluated. The relationship between miR-375 and clinical parameters of cervical cancer was analyzed. Results The expression of serum miR-375 in patients with cervical cancer was significantly lower than that in patients with CIN and healthy controls(both P<0.05). The level of serum miR-375 in CIN patients was significantly lower than that in healthy controls(P<0.05). Receiver operating characteristic(ROC)curve analysis showed that the area under the ROC curve(AUC)for serum miR-375 was 0.782(95% CI: 0.714-0.840; sensitivity, 73.4%; specificity, 78.9%), which was significantly higher than that of CA125［0.677, 95%CI: 0.603-0.745］, P<0.05. The expression of serum miR-375 was significantly up-regulated after surgery in the same subset of patients with cervical cancer(P<0.05). Moreover, serum miR-375 in patients with cervical cancer was significantly correlated with FIGO stages and lymphoid node metastasis(both P<0.05), while there was no significant association between serum miR-375 and 山 东 大 学 学 报 (医 学 版)54卷3期 -彭慧,等.血清循环miR-375检测对宫颈癌早期诊断及术后监测的意义 \=-age, histological type or cell differentiation(all P>0.05). Conclusion Serum miR-375 is conducive in the diagnosis of cervical cancer and CIN. It can serve as an index for the postoperative monitoring, progression and lymphoid node metastasis evaluation of cervical cancer.

Key words: Cervical cancer, CA125, Cervical intraepithelial neoplasia, MiR-375