JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (12): 67-70.doi: 10.6040/j.issn.1671-7554.0.2015.172

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Clinical significance of miRNA-206 expression in gastric stromal tumor

YAO Dongxue, ZHAO Qi, QIN Chengyong   

  1. Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Received:2015-02-10 Online:2015-12-10 Published:2015-12-10

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Abstract: Objective To evaluate the expression and significance of miRNA-206 in the development of gastric stromal tumor. Methods Fifty-three cases of the surgical specimens of gastric stromal tumor were collected. miRNA-206 levels in matched pairs of gastric stromal tumor and normal adjacent tissue samples were examined using qRT-PCR; the relationship between miRNA-206 levels and clinical characteristics were investigated. Results Expression of miRNA-206 was significantly lower in tumor than that in adjacent normal tissues (P<0.05). Expression of miRNA-206 in cases with mitotic count ≥ 5/50HPF was significantly lower than that with mitotic count<5/50HPF (P<0.05). By Fletcher risk stratification system, expression of miRNA-206 in intermediate/high-risk cases was significantly lower than that in very low/low risk cases (P<0.05). Conclusion In gastric stromal tumor, miRNA-206 expression is significantly down-regulated, and is closely associated with mitotic counts and Fletcher risk stratification system, which suggests that miRNA-206 play an important role in the process of development of gastric stromal tumor.

Key words: Gastric stromal tumors, Clinical characteristics, miRNA-206, Mitotic count, Fletcher risk stratification

CLC Number: 

  • R573
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