JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (11): 80-84.doi: 10.6040/j.issn.1671-7554.0.2015.317

• Clinical Medicine • Previous Articles     Next Articles

Clinical features and prognostic factors of cutaneous malignant melanoma in Shandong Province: report of 61 cases

ZHANG Min1, MU Xiaonan2, MA Weiyuan3, DANG Ningning1, ZHANG Nan4   

  1. 1. Department of Dermatology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China;
    2. Department of Health Care, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China;
    3. Department of Dermatology, Qilu Hospital, Shandong University, Jinan 250012, Shandong, China;
    4. Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China
  • Received:2015-03-24 Online:2015-11-10 Published:2015-11-10

PDF (PC)

542

Abstract: Objective To investigate the clinical features and prognostic factors of cutaneous malignant melanoma (CMM) in Shandong Province. Methods Clinical data of 61 CMM cases treated during Jan. 2009 and Dec. 2014 were retrospectively reviewed. The survival rates were calculated with Kaplan-Meier method and compared with log-rank test. The independent prognostic factors were evaluated with Cox regression multivariate analysis. Results The 1-year, 3-year and 5-year survival rates of the 61 patients were 82.0%, 23.0%, and 16.4%, respectively. The 5-year survival rate was significantly associated with clinical staging (P<0.01), ulceration (P<0.01), and operation (P<0.01). Clinical staging was the independent prognostic factor. Conclusion Clinical staging is the independent risk factor for poor survival rate in patients with CMM in Shandong Province.

Key words: Cutaneous malignant melanoma, Prognosis, Survival analysis, Shandong Province

CLC Number: 

  • R739.5
[1] Noveski L, Zhivadinovik J, Matveeva N. Prognostic factors of primary cutaneus melanoma[J]. Med Pregl, 2014, 67(11-12):392-398.
[2] Eriksson H, Frohm-Nilsson M, Järås J, et al. Prognostic factors in localized invasive primary cutaneous malignant melanoma:results of a large population-based study[J]. Br J Dermatol, 2015, 172(1):175-186.
[3] Gloster HM Jr, Brodland DG. The epidemiology of skin cancer[J]. Dermatol Surg, 1996, 22(3):217-226.
[4] Jeon SY, Hong JW, Lee S, et al. Long-term survival analysis and clinical follow-up in acral lentiginous malignant melanoma undergoing sentinel lymph node biopsy in korean patients[J]. Ann Dermatol, 2014, 26(2):177-183.
[5] Ozgen A. A single institution retrospective analysis of malignant melanoma[J]. J Cancer Res Ther, 2014, 10(1):38-42.
[6] Chi Z, Li S, Sheng X, et al. Clinical presentation, histology, and prognoses of malignant melanoma in ethnic Chinese:a study of 522 consecutive cases[J]. BMC Cancer, 2011, 11:85. doi:10.1186/1471-2407-11-85.
[7] Luk NM, Ho LC, Choi CL, et al. Clinicopathological features and prognostic factors of cutaneous melanoma among Hong Kong Chinese[J]. Clin Exp Dermatol, 2004, 29(6):600-604.
[8] Måsbäck A, Olsson H, Westerdahl J, et al. Prognostic factors in invasive cutaneous malignant melanoma:a population-based study and review[J]. Melanoma Res, 2001, 11(5):435-445.
[9] Bradford PT, Goldstein AM, McMaster ML, et al. Acral lentiginous melanoma:incidence and survival patterns in the United States, 1986-2005[J].Arch Dermatol, 2009, 145(4):427-434.
[10] Armstrong A, Powell C, Powell R, et al. Are we seeing the effects of public awareness campaigns? A 10-year analysis of breslow thickness at presentation of malignant melanoma in the south west of England[J]. J Plast Reconstr Aesthet Surg, 2014, 67(3):324-330.
[11] Roh MR, Kim J, Chung KY. Treatment and outcomes of melanoma in acral location in Korean patients[J]. Yonsei Med J, 2010, 51(4):562-568.
[12] Ishihara K, Saida T, Yamamoto A. Japanese skin cancer society prognosis and statistical investigation committee. updated statistical data for malignant melanoma in Japan[J]. Int J Clin Oncol, 2001, 6(3):109-116.
[13] 迟志宏, 盛锡楠, 李思明, 等. 357例中国皮肤黑色素瘤临床特征与预后分析[J]. 肿瘤防治研究, 2011, 38(11):1316-1319. CHI Zhihong, SHENG Xinan, LI Siming, et al. A clinical characters and prognosis analysis on 357 cases with cutaneous malign ant melanoma in China[J]. Cancer Research on Prevention and Treatment, 2011, 38(11):1316-1319.
[14] Cormier JN, Xing Y, Ding M, et al. Ethnic differences among patients with cutaneous melanoma[J]. Arch Intern Med, 2006, 166(17):1907-1914.
[15] Cascinelli N. Margin of resection in the management of primary melanoma[J]. Semin Surg Oncol, 1998, 14(4):272-275.
[16] Voss B, Wilop S, Jonas S, et al. Tumor volume as a prognostic factor in resectable malignant melanoma[J]. Dermatology, 2014, 228(1):66-70.
[1] PANG Jinhong, SU Ping, QIAO Junpeng, CHEN Qiaoqiao, CHEN Xueyu, ZHAO Yingying, SHI Jie, SUN Xiaoru, LI Qiuchun, HE Ruiyan, FAN Yiou, CHI Weiwei. Association between modifiable cardiovascular risk factors clustering patterns and stroke in the elderly population [J]. Journal of Shandong University (Health Sciences), 2025, 63(9): 11-19.
[2] LI Ziqi, WEI Yanruoxue, LIU Xiaohan, LIU Chuncheng, ZHAO Ran, LIU Yukun. The functional role and clinical significance of lncRNA HEATR3-AS1 in colorectal cancer tumorigenesis and progression [J]. Journal of Shandong University (Health Sciences), 2025, 63(9): 108-115.
[3] LIU Baoguo, SONG Xiang, ZHAO Xiaowen, MAO Yali. Application value of serum STAT5B and NKAIN1 mRNA detection in breast cancer [J]. Journal of Shandong University (Health Sciences), 2025, 63(7): 68-74.
[4] WANG Lei, CHANG Xiao, WANG Zimeng, LI Jiaojiao, CUI Shujun, YANG Fei, ZHU Yuexiang. Predictive value of intratumoral and peritumoral DCE-MRI imaging histology for progression-free survival in patients with cervical cancer [J]. Journal of Shandong University (Health Sciences), 2025, 63(6): 45-54.
[5] JIA Ruoxi, LYU Li, LIU Hanyun, WU Yinping, LI Fengcai, ZHAO Zehua, WANG Kai, FAN Yuchen. Diagnostic value of blood cell count-related biomarkers in predicting 28-day mortality in acute-on-chronic hepatitis b liver failure [J]. Journal of Shandong University (Health Sciences), 2025, 63(6): 89-99.
[6] DU Xue, LI Chunxia, LIU Yunxia, ZHANG Tao. Dynamic prediction model for the colorectal cancer patients prognosis based on MFPC-Cox [J]. Journal of Shandong University (Health Sciences), 2025, 63(5): 101-110.
[7] YANG Weifang, XU Hong, LIU Yuantao, ZHAO Huichen. Mechanism of thyroid-stimulating immunoglobulin in Graves disease recurrence and clinical significance [J]. Journal of Shandong University (Health Sciences), 2025, 63(4): 116-121.
[8] Thoracoscopic Committee of Shandong Provincial Endoscopic Surgery Quality Control Center. Shandong Provincial expert consensus on control indexes of VATS/RATS perioperative quality for non-small cell lung cancer [J]. Journal of Shandong University (Health Sciences), 2025, 63(12): 1-5.
[9] LIU Wenzhao, ZHANG Yuan, MA Xiangping, WEI Fengtao, BU Peili. Correlation between the pre-endothelial activation and stress index and the mortality risk of patients with heart failure [J]. Journal of Shandong University (Health Sciences), 2025, 63(11): 27-35.
[10] CHEN Wenliang, WANG Huanhuan, HAO Jinjin, GONG Rui, ZHAO Qiang, ZHANG Fei, GAO Lei, DONG Jingxun. The role of lncRNA PVT1 in prognostic assessment and malignant progression of gastric cancer: a study based on nomogram model and functional cellular experiments [J]. Journal of Shandong University (Health Sciences), 2025, 63(10): 61-71.
[11] . Shandong Province expert consensus on multidisciplinary treatment of breast cancer(2024 edition) [J]. Journal of Shandong University (Health Sciences), 2025, 63(1): 10-16.
[12] GUO Shuhua, FAN Yang, TIAN Feng, WANG Chuanxin, DU Lutao, LI Peilong, GUO Xing, XU Shuo. Role of microfibril-associated protein 3 in regulating mesenchymal transition of glioma stem cells [J]. Journal of Shandong University (Health Sciences), 2024, 62(6): 9-16.
[13] WEI Yanruoxue, LI Ziqi, LIU Chuncheng, LIU Xiaohan, ZHAO Ran, LIU Yukun. Intratumor heterogeneity of SP1 expression in colorectal cancer and its clinical significance [J]. Journal of Shandong University (Health Sciences), 2024, 62(5): 89-94.
[14] LIU Chuncheng, LIU Xiaohan, WEI Yanruoxue, LI Ziqi, LIU Yukun, ZHAO Ran. Subcellular localization pattern of bromodomain containing 9 in colorectal cancer and its clinical significance [J]. Journal of Shandong University (Health Sciences), 2024, 62(4): 24-30.
[15] YANG Xueyan, WU Yinping, LYU Li, ZHAO Zehua, MA Hangyu, LI Fengcai, WANG Kai, FAN Yuchen. Diagnostic value of dynamic changes of monocyte-to-lymphocyte ratio in acute-on-chronic hepatitis B liver failure [J]. Journal of Shandong University (Health Sciences), 2024, 62(3): 61-69.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd