JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (S1): 77-79.

Previous Articles     Next Articles

Correlations between serum levels of TP and clinical outcome in patients with advanced gastric cancer receiving S-1 regimen chemotherapy

XU Guang-hui1, LI Yu1, LIU Zhong-lun2, HU Nan1   

  1. 1. Department of Oncological Chemotherapy, The First People's Hospital of Lianyungang , Lianyungang 222002, Jiangsu China;
    2. Department of Laboratory, The First People's Hospital of Lianyungang , Lianyungang 222002, Jiangsu China
  • Received:2014-11-30 Published:2014-12-30
  • Contact: 李玉, E-mail: ly651226@163.com E-mail:ly651226@163.com

PDF (PC)

131

Abstract: Objective To investigate the correlations between serum levels of TP and clinical outcome in patients with advanced gastric cancer receiving S-1 regimen chemotherapy. Methods Serum samples before chemotherapy were collected from 46 patients receiving first-line S-1 regimen chemotherapy from Jun 2012 to Jan 2014, TP levels were analyzed using ELISA assay. Results TP expressions were significantly lower in patients with liver metastasis than those in patients without liver metastasis (P<0.01). There was no difference in clinical beneficial rate (CBR) between patients with high and low levels of TP. The median progression-free survival (PFS) in patients with high level of TP was longer than those with low level of TP (6.5 m vs 5.0 m,P=0.026 ). Conclusion In patients receiving first-line S-1 regimen chemotherapy, those with high level of TP may get better prognosis than those with low level of TP.

Key words: Gastric cancer, Thymidine phosphorylase, S-1, Prognosis

CLC Number: 

  • R735
[1] 夏传生,李娜萍,李明显,等.胸苷磷酸化酶及血管内皮生长因子在胃腺癌组织中的表达及其临床意义[J].华中科技大学学报: 医学版,2011,40(3): 343-346.
[2] Hata K,Fujiwaki R,Nakayama K,et al.Expression of thymidine phosphorylase and vascular endothelial growth factor in epithelial ovarian cancer: correlation with angiogenesis and progression of the tumor [J].Anticancer Res,1999,20(5C): 3941-3949.
[3] Fujiwaki R,Hata K,Nakayama K,et al.Gene expression for dihydropyrimidine dehydrogenase and thymidine phosphorylase influences outcome in epithelial ovarian cancer[J].J Clin Oncol,2000,18(23): 3946-3951.
[4] Matsuura T,Kuratate I,Teramachi K,et al.Thymidine phosphorylase expression is associated with both increase of intratumoral microvessels and decrease of apoptosis in human colorectal carcinomas[J].Cancer Res,1999,59(19): 5037-5040.
[5] Takebayashi Y,Miyadera K,Akiyama S,et al.Expression of thymidine phosphorylase in human gastric carcinoma[J].Cancer Science,1996,87(3): 288-295.
[6] Fujioka S,Yoshida K,Yanagisawa S,et al.Angiogenesis in pancreatic carcinoma [J].Cancer,2001,92(7): 1788-1797.
[7] 何琼,高静,王婷婷,等.晚期胃癌患者血清 TS、TP 表达水平与氟尿嘧啶为基础的化疗疗效及预后的相关性[J].中国癌症杂志,2013,23(4): 292-297.
[8] Nishimura G,Terada I,Kobayashi T,et al.Thymidine phosphorylase and dihydropyrimidine dehydrogenase levels in primary colorectal cancer show a relationship to clinical effects of 5'-deoxy-5-fluorouridine as adjuvant chemotherapy [J].Oncol Rep,2002,9(3): 479-482.
[9] Zhou J,Xiao Y S,Tang Z Y,et al.Transfection of thymidine phosphorylase cDNA to human hepatocellular carcinoma cells enhances sensitivity to fluoropyrimidine but augments endothelial cell migration [J].J Cancer Res Clin Oncol,2005,131(8): 547-551.
[1] YU Jia-Zhi, WANG Ke-Lai, ZHUANG Yan, ZHANG Lian-Hai. Expression of S-100 and C-kit in child primary obstructive megaureter [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 73-.
[2] LI Ziqi, WEI Yanruoxue, LIU Xiaohan, LIU Chuncheng, ZHAO Ran, LIU Yukun. The functional role and clinical significance of lncRNA HEATR3-AS1 in colorectal cancer tumorigenesis and progression [J]. Journal of Shandong University (Health Sciences), 2025, 63(9): 108-115.
[3] LIU Baoguo, SONG Xiang, ZHAO Xiaowen, MAO Yali. Application value of serum STAT5B and NKAIN1 mRNA detection in breast cancer [J]. Journal of Shandong University (Health Sciences), 2025, 63(7): 68-74.
[4] WANG Lei, CHANG Xiao, WANG Zimeng, LI Jiaojiao, CUI Shujun, YANG Fei, ZHU Yuexiang. Predictive value of intratumoral and peritumoral DCE-MRI imaging histology for progression-free survival in patients with cervical cancer [J]. Journal of Shandong University (Health Sciences), 2025, 63(6): 45-54.
[5] JIA Ruoxi, LYU Li, LIU Hanyun, WU Yinping, LI Fengcai, ZHAO Zehua, WANG Kai, FAN Yuchen. Diagnostic value of blood cell count-related biomarkers in predicting 28-day mortality in acute-on-chronic hepatitis b liver failure [J]. Journal of Shandong University (Health Sciences), 2025, 63(6): 89-99.
[6] DU Xue, LI Chunxia, LIU Yunxia, ZHANG Tao. Dynamic prediction model for the colorectal cancer patients prognosis based on MFPC-Cox [J]. Journal of Shandong University (Health Sciences), 2025, 63(5): 101-110.
[7] YANG Weifang, XU Hong, LIU Yuantao, ZHAO Huichen. Mechanism of thyroid-stimulating immunoglobulin in Graves disease recurrence and clinical significance [J]. Journal of Shandong University (Health Sciences), 2025, 63(4): 116-121.
[8] ZHANG Jie, ZHAO Yinghui, DONG Yaqi, LI Juan, LI Peilong, DU Lutao. Role of GPR133 gene methylation in predicting lymph node metastasis in early gastric cancer [J]. Journal of Shandong University (Health Sciences), 2025, 63(3): 76-84.
[9] LIU Wenzhao, ZHANG Yuan, MA Xiangping, WEI Fengtao, BU Peili. Correlation between the pre-endothelial activation and stress index and the mortality risk of patients with heart failure [J]. Journal of Shandong University (Health Sciences), 2025, 63(11): 27-35.
[10] CHEN Wenliang, WANG Huanhuan, HAO Jinjin, GONG Rui, ZHAO Qiang, ZHANG Fei, GAO Lei, DONG Jingxun. The role of lncRNA PVT1 in prognostic assessment and malignant progression of gastric cancer: a study based on nomogram model and functional cellular experiments [J]. Journal of Shandong University (Health Sciences), 2025, 63(10): 61-71.
[11] GUO Zhenjiang, WANG Ning, ZHAO Guangyuan, DU Liqiang, CUI Zhaobo, LIU Fangzhen. Development of preoperative models for predicting positive esophageal margin in proximal gastric cancer based on machine learning [J]. Journal of Shandong University (Health Sciences), 2024, 62(7): 78-83.
[12] GUO Shuhua, FAN Yang, TIAN Feng, WANG Chuanxin, DU Lutao, LI Peilong, GUO Xing, XU Shuo. Role of microfibril-associated protein 3 in regulating mesenchymal transition of glioma stem cells [J]. Journal of Shandong University (Health Sciences), 2024, 62(6): 9-16.
[13] WEI Yanruoxue, LI Ziqi, LIU Chuncheng, LIU Xiaohan, ZHAO Ran, LIU Yukun. Intratumor heterogeneity of SP1 expression in colorectal cancer and its clinical significance [J]. Journal of Shandong University (Health Sciences), 2024, 62(5): 89-94.
[14] BAI Xiaoliang, SUN Panpan, WANG Hongli, GONG Shunzhi, SUN Yunqi, SHU Meng, QI Xiaoliang. Animal experiment of medical thoracoscopic splanchnotomy [J]. Journal of Shandong University (Health Sciences), 2024, 62(4): 9-13.
[15] LIU Chuncheng, LIU Xiaohan, WEI Yanruoxue, LI Ziqi, LIU Yukun, ZHAO Ran. Subcellular localization pattern of bromodomain containing 9 in colorectal cancer and its clinical significance [J]. Journal of Shandong University (Health Sciences), 2024, 62(4): 24-30.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd