JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (9): 81-84.doi: 10.6040/j.issn.1671-7554.0.2014.291

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Immunohistochemical analysis of Helicobacter pylori infection in children

XU Cui1, WANG Tao1, ZHOU Ping2   

  1. 1. Department of Pediatrics First Hospital of Zibo City, Zibo 255200, Shandong, China;
    2. Department of Pathology, First Hospital of Zibo City, Zibo 255200, Shandong, China
  • Received:2014-05-06 Revised:2014-09-06 Online:2014-09-10 Published:2014-09-10
  • Contact: 王涛。E-mail:zberke@21cn.com E-mail:zberke@21cn.com

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Abstract: Objective To assess the diagnostic value of immunohistochemical staining of Helicobacter pylori (Hp) infection in children. Methods A total of 102 children who had upper gastrointestinal discomfort were recruited among the pediatric outpatients. Endoscopy, antral mucosal biopsy, rapid urease test (RUT) and immunohistochemical staining were performed. Before endoscopy, 13C-UBT and current infection marker (CIM) were used to detect the Hp infection. Parameters including sensitivity, specificity, and accuracy were determined by 13C-UBT. Results There was no significant statistical difference in the sensitivity, specificity and accuracy between immunohistochemistry and CIM, and between immunohistochemistry and RUT. Conclusion Immunohistochemical staining is a simple, accurate, and reliable method to determine Hp infection in children patients.

Key words: Helicobacter pylori, Immunohistochemistry, Rapid urease test, 13C Urea breath test, Current infection marker, Child

CLC Number: 

  • R725
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