JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2013, Vol. 51 ›› Issue (5): 105-107.

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Association of urokinase gene 3′-UTR ploymorphism with diopathic calcium oxalate stone

XI Hai-bo， FU Long-long， WANG Gong-xian， FU Bin， LI Yu， SONG Xiao-fen   

  1. Department of Urology， The First Affiliated Hosptial of Nanchang University，  Nanchang 330006, China
  • Received:2012-11-21 Online:2013-05-10 Published:2013-05-10

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Abstract:

 Objective   To explore the association between urokinase gene 3′- UTR T/C polymorphism and idiopathic calcium oxalate urolithiasis. Methods   142 healthy people without history of stone formation and 138 people with idiopathic calcium oxalate stones were engaged in this study. Urokinase gene 3′-UTR T/C polymorphism was determined by polymerase chain reaction and restriction fraction length polymorphism(PCR-RFLP). Results   The difference of TT and CT+CC genotype frequencies between the two groups was significant(P<0.05) . The difference of T and C allele frequencies between the two groups was also significant(P<0.05). Allele T was an risk factor for the idiopathic calcium oxalate nephrolithiasis. The idiopathic calcium oxalate nephrolithiasis incidence risk of the T gene carrier was 1. 493 times higher compared with allele C. Conclusion   There is significant association between urokinase gene 3′ UTR T/C polymorphism with idiopathic calcium oxalate urolithiasis.

Key words: Urolithiasis; Idiopathic calcium oxalate stones; Single nucleotide polymorphism

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