JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (10): 72-76.doi: 10.6040/j.issn.1671-7554.0.2014.222

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Value of acoustic radiation force impulse imaging technology for differentiating benign from malignant thyroid nodules

JIANG Lili1, MA Zhe2, MA Chuyun3, HE Yuanliu1, TAO Guowei2, LIU Cun1, GENG Qun4, TANG Tingting5, WANG Yin4   

  1. 1. Department of Ultrasonography, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China;
    2. Department of Ultrasonography, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    3. Department of Ultrasonography, Chengdu Military General Hospital, Chengdu 610083, Shandong, China;
    4. School of Medicine, Shangdong University, Jinan 250012, Shandong, China;
    5. Department of Ultrasonography, Jinan Fourth People's Hospital, Jinan 250031, Shandong, China
  • Received:2014-04-14 Revised:2014-09-11 Online:2014-10-10 Published:2014-10-10

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Abstract: Objective To evaluate the diagnostic value of virtual touch tissue quantification (VTQ) of acoustic radiation force impulse (ARFI) elasticity imaging for differentiating benign from malignant thyroid lesions. Methods Two hundred and sixty-eight patients with 312 thyroid nodules undergoing thyroid nodules surgeryor biopsies after thyroid nodules VTQ examination were retrospectively reviewed. The patients were selected from the Department of Ultrasonography, Qilu Hospital of Shandong University,during Sep. 2011 to Oct. 2012. All cases were divided into four groups, benign nodules group(n=196),parenchyma surrounding benign nodules group(n=196), malignant nodules group(n=116), and parenchyma surrounding malignant nodules group(n=116), according to the pathological results. TheVTQ values of the four groups were detected and statistically analyzed. Results ①VTQ value of malignant thyroid nodules group was significantly higher than those of the other groups(P<0.001);②No significant difference was found among the VTQ values of parenchyma surrounding benign nodules group, benign nodules group and parenchyma surrounding malignant nodules group(P=0.174, P=0.812, P=0.063);③According to the receiver operating characteristic(ROC) curve, 3.25 m/s was determined as the optimized point of the diagnostic value. When an SWV greater than 3.25 m/s was used for the diagnosis of malignant nodules and less than 3.25 m/s for the diagnosis of benign nodules, the sensitivity and specificity of ARFI imaging were 89% and 70%, respectively. Conclusion VTQ technology is more objective in quantitatively evaluating tissue hardness. VTQ technology shows better diagnostic value in the evaluation of benign and malignant thyroid nodules.

Key words: Acoustic radiation force impulse technology, Virtual touch tissue quantification, Differentiation, Thyroid nodules

CLC Number: 

  • R445.1
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