JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

Significance of ETV6 rearrangement in acute myelogenous leukemia-M4Eo

GAO Na1,LI Zhi-hong2,DING Bu-tong3，CHEN Yun1，WANG Yun-shan3，GUO Nong-jian1   

  1. 1. Department of Hematology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250012, China;2. Xinglong Colliery Hospital of Yanzhou Mining Group
  • Received:2007-12-15 Revised:1900-01-01 Online:2008-04-16 Published:2008-04-16
  • Contact: GUO Nong-jian

PDF (PC)

1950

Abstract: To explore the clinical significance of ETV6 gene rearrangement involved in acute myelogenous leukemia M4Eo. Methods3 cases of AML -M4Eo were prepared the chromosome after the bone marrow cells culture. R-banding technique was used to analyze the karotypes. 12p13 translocation was determined by Split-signal FISH in the interphase and metaphase cells. ETV6/ARG fusion genes were analyzed by RT-PCR. ResultsClone chromosomal abnormalities with inv(16) was found by Karotype analysis in 3 cases, abnormal fluorescence signal with 12p13 translocation was found in 1 case by split-signal FISH, and ETV6/ARG fusion gene was found by RT-PCR. This was the second report that ETV6/ARG expressed in AML－M4Eo. ConclusionThis patient is not sensitive to chemical therapy, even has worse prognosis than patient without this fusion gene. Splitsignal FISH is a reliable measure to detect ETV6 gene rearrangement.

Key words: Leukemia, ETV6, In situ hybridization, RT-PCR

CLC Number: 

  • R557+.3
[1] LI Ziqi, WEI Yanruoxue, LIU Xiaohan, LIU Chuncheng, ZHAO Ran, LIU Yukun. The functional role and clinical significance of lncRNA HEATR3-AS1 in colorectal cancer tumorigenesis and progression [J]. Journal of Shandong University (Health Sciences), 2025, 63(9): 108-115.
[2] YANG Wenxin, LIU Yingjiao, GAO Ya, YANG Anyi, ZHOU Hengyu, GAO Juncha. Acute pancreatitis as initial manifestation in a patient with acute myeloid leukemia: a case report and literature review [J]. Journal of Shandong University (Health Sciences), 2023, 61(7): 109-117.
[3] DONG Hongjie, ZHANG Junmei, WANG Shuai, WANG Hongwei, ZHANG KundiHU Wei, XIE Xiaohong, XIE Shiling, GU Lichuan. Research on mixed sample test for SARS-CoV-2 [J]. Journal of Shandong University (Health Sciences), 2021, 59(4): 1-5.
[4] ZHANG Xiaohui, LUO Jianmin, SUO Xiaohui, SUN Guofeng, LI Jing. Relationship between methylation of tumor suppressor genes SOCS1 and SOCS3 and remission and prognosis of 80 acute myeloid leukemia patients [J]. Journal of Shandong University (Health Sciences), 2021, 59(3): 67-73.
[5] ZENG Rui, HU Xinting, YUN Xiaoya, TIAN Zheng, LI Qing, LIU Jie, ZHANG Ya, WANG Xin. Fluorescence in situ hybridization in the diagnosis of 197 cases of chronic lymphocytic leukemia [J]. Journal of Shandong University (Health Sciences), 2021, 59(11): 35-40.
[6] WANG Yan, ZHANG Yuhui, HU Naibo, TENG Guangshuai, ZHOU Yuan, BAI Jie. Characteristics of bone marrow immune microenvironment in patients with acute myeloid leukemia based on single-cell RNA sequencing [J]. Journal of Shandong University (Health Sciences), 2021, 59(10): 32-40.
[7] ZHAO Huailong, LÜ Yan, ZHAO Hong, ZHAO Baotian, HAN Ying, YANG Guoliang, WANG Chunrong, GUAN Hengyun, LIU Hui, LIU Lanzheng. Effect of sampling positions in nucleic acid test on the test result: a report from 47 confirmed COVID-19 cases in Jinan City [J]. Journal of Shandong University (Health Sciences), 2020, 58(4): 28-31.
[8] DAI Xiaoyu, LU Yuan, WANG Zhiheng, LI Mingzhuo, SI Shucheng, LI Jiqing, JING Ming, XUE Fuzhong. Value of blood routine data in distinguishing myelodysplastic syndrome and acute myeloid leukemia [J]. Journal of Shandong University (Health Sciences), 2020, 58(1): 20-25.
[9] WANG Jianxiang, GU Runxia. Advances in targeted therapy for acute myeloid leukemia [J]. Journal of Shandong University (Health Sciences), 2019, 57(7): 6-12.
[10] LI Jianyong, XIA Yi, XU Wei. Selecting therapy for chronic lymphocytic leukemia in the era of novel agents [J]. Journal of Shandong University (Health Sciences), 2019, 57(7): 21-30.
[11] SUN Feifei, FANG Xiaosheng, JIANG Yujie, SUI Xiaohui, LIU Xin, WANG Xianghua, LI Ying, ZHANG Lingyan, XU Hongzhi, WANG Xin. Graft-versus-host disease secondary to allogeneic hematopoietic stem cell transplantation in 57 patients with acute lymphoblastic leukemia [J]. Journal of Shandong University (Health Sciences), 2019, 57(7): 61-66.
[12] LI Xue, LI Dong, SHI Qing, ZHOU Panpan, JU Xiuli. Expression and role of Helios gene in regulatory T cells of pediatric precursor B-cell acute lymphoblastic leukemia [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(4): 76-81.
[13] ZHOU Lanlan, PAN Xueyi, GUO Yu. Clinical characteristics and prognosis of 48 patients with mixed phenotype acute leukemia [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(2): 79-83.
[14] YANG Juan, QIU Zongjian, SONG Qiang. Impacts of Simvastatin on DNA methyltransferase of cell line NB4 in acute myeloid leukemia [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(6): 28-32.
[15] GU Xu, WANG Xiaqing, REN Wanhua, QIN Chengyong, HAN Guoqing. Expression and clinical significance of NPRL2 and Survivin in hepatocellular carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(6): 68-72.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd