Abstract:

Objective      To explore the effect of different balanced ultrafiltration(BUF) volumes on inflammatory mediators in cardiopulmonary bypass(CBP). Methods      80 children with congenital heart disease were randomly divided into 4 groups: the control group (group C ), the low ultrafiltrate volume(UFV) group［group L, UFV=30mL/(kg·h)］, the moderate UFV group ［group M, UFV=60mL/(kg·h)］, and the high UFV group ［group H, UFV=90mL/(kg·h)］. All of the groups were given modified ultrafiltration after termination of CPB. Serum TNF-α, IL-6 and IL-8 were measured at the beginning and termination of CPB, and 2 and 12 hours postoperatively. Results      During CPB, concentrations of TNF-α, IL-6 and IL-8 showed increasing trends in all groups, while the trends were less significant in UFV groups than in group C. After termination of CPB, concentrations of TNF-α, IL-6 and IL-8 were significantly lower in UFV groups than in group C. Compared among UFV groups, concentrations of TNF-α, IL-6 and IL-8 in group L were higher than those in groups M and H (P<0.05), while they had no statistically significant difference between groups M and H. Conclusion      UFV=60mL/(kg · h) is more reasonable for BUF strategy.

Key words: Cardiopulmonary bypass; Balanced ultrafiltration; Tumor necrosis factor-α; Interleukin-6; Interleukin-8