Abstract:

Objective      To discuss the relation of C-reactive protein(CRP) and coronary artery lesions(CAL) secondary to Kawasaki disease(KD) in children. Methods      Papers and dissertations about relations of CRP and CAL secondary to KD published between January 2000 and December 2009 were retrieved from Chinese Databases. RavMan 4.2 provided by Cochrane Network was used for Meta analysis of count data. Fixed effects model was selected according to the heterogeneity test results of the literature. Sensitivity analysis was performed according to the different results. The publication bias was evaluated by funnel plots， and odds ratio (OR) and 95% confidence interval (95% CI) were estimated. Weighted mean difference(WMD) and 95% CI was used to analyze measurement data. Results      19 studies met the inclusion criteria. Statistical analysis results of the count data were as follows: CRP>100mg / L［OR=2.37,95% CI=(1.49,3.77), P=0.0003］; Statistical analysis results of the measurement data were as follows: WMD=19.02, 95%, CI=(11.98,26.05), P<0.00001. Conclusion      CRP is closely related to CAL secondary to KD, and CRP>100mg /L is one of its risk factors.

Key words: C-reactive protein; Kawasaki disease; Coronary artery lesion；Meta analysis