Abstract:

Objective    To analyze the features of type 2 diabetic retinopathy (DR), and to explore the relationship between serum cystatin C ( Cys-C ), high sensitivity C-reactive protein (hsCRP) and retinopathy in the patients with type 2 diabetes. Method    325 cases of type 2 diabetes patients were recruited to perform fundus examination and fundus fluorescence angiography. Based on the findings, 5 groups were establised according to 2002 international classification standard, incluidng no obvious retinopathy (group 1), mild nonproliferating diabetic retinopathy (group 2), moderately non-proliferating diabetic retinopathy (group 3), severe nonproliferating diabetic retinopathy ( group 4), and proliferating diabetic retinopathy (group 5). Clinical courses were monitered, while glycated hemoglobin(HbA1c), hs-CRP, Cys-C, 24-hour urinary albumin quantitative (24hUAE) were determined. Results     In all the cases,  total DR prevalence accounted for about 47 percent; Compared with the group 1, clinical courses, HbA1c, hs-CRP, Cys-C, 24h-UAE in the other four groups were significantly increased (P<0.05), at the order from group 2 to 5 (P<0.05); Multiple regression analysis showed that Cys-C, hs-CRP were the independent risk factors for DR prevalence rate and the severity of DR, and were positively correlated with the duration of type 2 diabetes, the sicken HbA1c and 24h-UAE, respectively. Conclusions     The DR and the severity are closely related with Cys-C and hs-CRP.  Cys-C, hs-CRP may serve as the biological indicators to predict the occurrence and development of DR.

Key words: High sensitivity C-reactive protein ; Cystatin C ; Retinopathy; Type 2 diabetes mellitus