Abstract: To explore the effect of Lapppaconitine on glucose, cortisol andβendorphine in surgeries. Methods 45 patients suffering from nucleus pulposus of the lumbar, lumbar spinal stenosis, and lumbar spondylolisthesis were randomly divided into 3 groups(n=15). The group of Lapppaconitine: 8mg Lappaconitine was intravenously infused 30?min before total intravenous anaesthesia(TIVA) and kept in a speed of 0.28mg/mL during the operations, and then 8mg Lappaconitine was given after the operations, and PCIA（patientcontrolled intravenous analgesia） started as soon as the patients woke up from anaesthesia. The total dose of lappaconitine was 48mg. The group of Tramadol: 100mg Tramadol was intravenously infused 30min before TIVA and kept in a speed of 8?mg/mL during the operations. PCIA started as soon as the patients woke up from anaesthesia. Tramadol(100mg) was infused before PCIA(the total dose of Tramadol was 1g). The control group: TIVA without either Lappaconitine or Tramadol during the operations or PCIA was performed on each patient. After operation, pethidine(50mg) and droperidol(2.5mg)were used to relieve the pain. The levels of glucose, cortisol and β-endorphine were determined at 30?min before anaethesia, the end of surgery, 24h and 48h after operations. ResultsThere were no significant differences before surgery in each group（P＞0.05）. The norm of glucose: compared with that before surgery, the level of glucose was significantly increased just at the end of surgery and 24h after surgery in group Tramadol（P＜0.05） and at 24h after surgery in group Lapppaconitine, also the level of glucose was significantly increased in the control group（P＜0.05）. There were significant differences between the control group and the Lapppaconitine group (P＜0.05）. The norm of cortisol: there were significant differences between the group of Lapppaconitine and the group of Tramadol just at the end of surgery and 24?h after surgery（P＜0.05）, also there were significant differences between the control group and the Lapppaconitine group（P＜0.05）. The norm of plasma βendorphine: there were significant differences between the tramadol group and the Lapppaconitine group（P＜0.05）, between the pre- and post-operative control groups（P＜0.05 or P＜0.01）, and between the postoperative control group and the Lapppaconitine group（P＜0.05 or P＜0.01）. ConclusionLappaconitine can decrease the levels of glucose, cortisol and β-endorphine.

Key words: Lappaconitine, Stress, Hypothalamuspituitaryadrenal cortex system