Abstract: To determine parameters affecting the longterm survival of patients with T2 stage transitional cell carcinoma of the bladder. MethodsFrom 1984 to 2004, 105 patients with T2M0 transitional cell carcinoma of bladder were treated, of which 85 patients were followed up. The possible survivalrelated factors including clinical and pathological figures were analyzed by Cox′s proportional hazard model in these patients. Results The 3-year and 5-year disease specific survival rates were 77.65% and 65.88%. Parameters affecting the longterm survival were: regional lymph nodes metastasis(the hazard ratio was 4.809), course over 2 month (the hazard ratio was 3.035), grade(the hazard ratio was 2.781), multiple tumors(the hazard ratio was 2.710), and the intravesical instillation of Bacille CalmetteGuérin was superior to the instillation of mitomycin C(the hazard ratio was 0.692). ConclusionsRegional lymph nodes metastasis plays an important role in the decision of the therapeutic regimen. BCG instillation is a good choice for patients who can not endure their side effects and choose the instillation of drugs such as mitomycin C. Survival time and life quality can be improved by prompt diagnosis and treatment.

Key words: Bladder neoplasms, Carcinoma, Transitional cell, Administration, Intravesical, Prognosis