JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Proportional changes of HBeAg negative chronic hepatitis B and liver cirrhosis B and the HBV genotype in Shandong Province

LIU You-de1，WANG Lei1，ZHOU Pei-jing1，ZHUANG Hui2   

  1. 1. Jinan Hospital of Infectious Disease, School of Medicine, Shandong University, Jinan 250021, China; 2. Department of Microbiology, Peking University Health Science Center
  • Received:2007-07-30 Revised:1900-01-01 Online:2008-01-16 Published:2008-01-16
  • Contact: WANG Lei

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Abstract: To investigate the proportional changes of HBeAg negative chronic hepatitis B(CHB) and liver cirrhosis of hepatitis B (LC-B) and the HBV genotype in Shandong Province. MethodsThe clinical data of 2?561 hospitalized cases of CHB and LC-B from 1996, 2001 and 2006 were retrospectively analyzed. The HBV genotypes were determined in 220 patients with CHB or LC-B by using the nested polymerase chain reaction based on genotype specific primers. ResultsThe proportion of HBeAg-negative LC-B(50.0%) was higher than that of CHB(23.8%), P＝0.000. It rose from 46.1% in 1996 to 54.4% in 2006, P＝0.047. The percentages of genotype C and B/C mixed genotypes in the HBeAg negative CHB and LC-B groups were 94.7%, 5.3% and 90.0% 10.0% respectively, which were not statistically different from the percentage in the HBeAg positive group. No genotype B or other genotypes were found. ConclusionsIn Shandong Province, HBeA positive is still the predominant form of hospitalized CHB, the proportion of HBeAgnegative LCB has been recently more than 50%. Genotype C is the predominant genotype in both HBeAg negative and positive patients. No genotype B is found in HBeAg negative patients.

Key words: Hepatitis B, chronic, Liver cirrhosis hepatitis B, Hepatitis B, E antigen, Hepatitis B virus, Genotype

CLC Number: 

  • R512.6+2
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