Abstract:

 Objective    To detect and compare the effect of the traditional Chinese drugs, Dipsacaceae and Salvia, on the reconstruction of paradentium in orthodontic teeth movement. Methods    72 female, 8-week-old SPF Wistar rats were selected and the animal models for orthodontic tooth movement were established. The rats were divided into three groups randomly: Dipsacaceae group, Salvia group and control group. Each group had 24 rats. Dipsacus asperoides decoction(6g/kg), Salvia decoction(6 g/kg)  and 3mL NS were drenched daily to the rats in the Dipsacaceae group, Salvia group and  control group respectively.  Stability of the appliances were checked everyday and the applied force was raised by adjusting the springs every 7 days. The rats were executed in batch on the 7th、14th、21st、28th day by peeling off the skulls. Distances of the teeth movement were measured and slices of the periodontium of the maxillary first molar were observed under optical microscope. Data were analyzed with PASWstatistics18. Results    Teeth movement in the Dipsacaceae group and Salvia group were greater than control group（P＜0.05）while  no significant difference（P＞0.05）was found between them. Light microscope revealed the number of osteoclasts in all 3 groups increased rapidly at the beginning but flatly later. Osteoclasts in  Dipsacaceae and Salvia group showed much more increase than the control （P＜0.05）, however, no significant difference existed between them(P＞0.05). Though alveolar bone density showed the trend of decrease in all 3 groups, Dipsacaceae and Salvia group decreased slowly(P＜0.05) and nosignificance was discovered between the two(P＞0.05). Conclusion    Salvia and Dipsacaceae decoction can promote the multiplication and differentiation of the osteoclasts in rats, benefit  alveolar bone reconstruction and accelerate orthodontic tooth movement.

Key words: Dipsacaceae; Salvia; Orthodontic tooth movement; Wistar rat