JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2010, Vol. 48 ›› Issue (7): 115-118.

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Variation and significance of peripheral blood matrix metalloproteinase-2 and interleukin-18  in patients with acute coronary  syndrome

CHEN Tao, ZHANG Xuhong， ZHU Xinglei   

  1. Department of cardiology, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China
  • Received:2010-03-15 Online:2010-07-16 Published:2010-07-16

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Abstract:

Objective   To investigate the concentration changes of  matrix  metalloproteinase-2(MMP-2), interleukin-18(IL-18) and fibrinogen in patients with acute-coronary syndrome(ACS)and their significance. Methods   Levels of MMP-2 and IL-18 were measured by ELISA in 32  patients with unstable angina pectoris (UAP) , 24 patients with acute myocardial infarction (AMI) ,36 patients with SAP (stable angina pectoris)and 40 healthy subjects. The level of fibrinogen was measured with the Clauss method. Results  Levels of MMP-2 and IL-18 were higher in the UA and AMI groups than in the SAP group and control group(P＜0.05﹚, while there was no significant difference in the level of fibrinogen among the four groups﹙P＞0.05﹚. In patients with ACS, the peak value of MMP-2 appeared on day 1, followed by a gradual decrease up to day 10, whereas IL-18 on day 3. Conclusion   MMP-2 and IL-18 play an important role in the pathogenesis of ACS.

Key words: Acute coronary syndrome; Matrix metalloproteinase-2; Interleukin-18

CLC Number: 

  • R541.4
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