Abstract:

Objective  To investigate expression of DC-lysosomal-associated membrane protein(DC-LAMP）and Dendritic-cell specific ICAM-3 grabbing non-integrin(DCSIGN) on Dendritic cells in Psoriasis vulgaris, and to explore the role of DC-LAMP and DC-SIGN in Psoriasis vulgaris. Methods  Expressions of DC-LAMP and DC-SIGN in lesions of Psoriasis vulgaris and normal skin were detected by immunohistochemistry. Results  DC-LAMP were highly expressed in  keratinocytes in the basal layer and spinous layer of the epidermis and Dendritic cells in the dermis of Psoriasis vulgaris,while lowly expressed in the basal layer of the epidermis and Dendritic cells in the dermis of normal skin (P<0.01). DC-SIGN were highly expressed in keratinocytes of Psoriasis vulgaris and Dendritic cells in the dermis,while lowly expressed in keratinocytes in the basal layer of the epidermis and Dendritic cells in the  dermis of normal skin (P<0.01). Conclusion  The pathogenesis of Psoriasis vulgaris may be related with DC-LAMP and DC-SIGN. Denritic cells and keratinocytes might play antigen-presenting roles by expressing DC-LAMP and DC-SIGN involved in the immune reaction of Psoriasis.

Key words: Psoriasis; Dendritic-cells lysosomal-associated membrane protein；Dendritic-cell specific ICAM-3 grabbing non-integrin