JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Effects of immunoglobulin on GABA receptors and expression of GAD in epileptic rats

YAN Hui-lan1，WANG Juan2，ZHAO Li-xia1   

  1. 1. Department of Pharmacy， 2. Department of Drug Purchase and Supply, Qilu Hospital of Shandong University, Jinan 250012, China
  • Received:2007-09-03 Revised:1900-01-01 Online:2008-01-16 Published:2008-01-16
  • Contact: YAN Hui-lan

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Abstract: To study the effects of immunoglobulin on the number of GABA receptors, the expression of GAD and cell apoptosis. Methods Forty healthy SD rats were randomly divided into the blank control group, the epilepsy model control group, the epilepsy model saline (NS) pretreatment group and the epilepsy model immunoglobulin pretreatment group. After being decapitated, the number of GABA receptors, the expression of GAD and cell apoptosis in the brains were determined. ResultsAfter seizures, the number of GABA receptors and the expression of GAD were higher in the model group than those in the control group. After immunoglobulin pretreatment, the number of GABA receptors and the expression of GAD were significantly increased while the number of apoptosis was decreased in the model group. Conclusion Immunoglobulin can control epilepsy by enhancing the expression of GAD and blocking apoptosis.

Key words: Epilepsy, Rats, Immunoglobulin, Receptors, GABA

CLC Number: 

  • R285.5
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