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Human cytomegalovirus infection upregulates expression of LOX1 in
rabbit smooth vascular muscle cells

LEI Xueming1,　LI Shuying1,　DONG Bo2,　PENG Ying1,　TANG Wei1, QI Mei1,LIU Juan1,　SUN Yundong1,　YU Han1,　ZHOU Yabin1
   

  1. (1. Department of Microbiology, School of Medicine, Shandong University, Jinan 250012, China;
    2. Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China)
  • Received:1900-01-01 Revised:1900-01-01 Online:2009-02-16 Published:2009-02-16
  • Contact: ZHOU Yabin

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Abstract: To investigate the effect of human cytomegalovirus(HCMV) infection on expression of lectinlike oxidized lowdensity lipoprotein receptor1 in rabbit smooth vascular muscle cells, and to show its role in the formation of atherosclerosis (AS). MethodsExpression of LOX1 in rabbit smooth vascular muscle cells which were affected by HCMV ADl69 was analyzed by reverse transcriptionpolymerase chain reaction and Western blotting. ResultsHCMV infection upregulated the expression of LOX1 in rabbit smooth vascular muscle cells. ConclusionHCMV infection upregulates the expression of LOX1 and this may be one of the mechanisms by which Human cytomegalovirus is involved in atherosclerosis．

Key words: Cytomegalovirus, Receptors,Lipoprotein, Smooth muscle cell

CLC Number: 

  • R373
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