Abstract: To explore the Adsorptive Voltammetric Behavior of Prulifloxacin. MethodsIn a supporting electrolyte of 03?mol·L-1KH2PO4NaH2PO4(pH64), a reduction peac of Prulifloxacin (PLF) with a potential of-102?V (vs Ag／AgCL) and adsorptive characteristics were observed by linear sweep voltammetry at the Hg electrode. ResultsThe adsorbed species were most probably the neutral molecules of PLF. The saturated adsorption amount of 401×10-11mol·cm-2 and an area occupied by each molecule of 202?nm2 at Hg electrode for PLF were obtained. On the surface of the hanging mercury drop electrode, the adsorption obeyed a langmuir adsorption isotherm. The adsorption coefficient β, the Gibbs energy of adsorption ΔGθ at 25?℃,　the number of electrons transferred n, the kinetic parameter of the irrepersible system αnα and the rate constant of surface electrode reaction ks　were 108×106,　-2914?KJ·mol-1,　2,101 and 027?s-1, respectively. ConclusionA method for PLF assay was proposed by adsorptive stripping voltammetry. The detection limit of the method is 20×10-8 mol·L-1 under the optimized conditions.

Key words: Prulifloxacin, Adsorptive stripping voltammetry, Electrochemical behavior, Pharmaceutical analysis