参芪解毒汤治疗慢性肾功能衰竭的实验研究

山东大学学报(医学版)

参芪解毒汤治疗慢性肾功能衰竭的实验研究

李云，司国民，张芸

山东大学山东省立医院中医科，山东济南 250021

收稿日期:2007-03-05 修回日期:1900-01-01 出版日期:2007-10-24 发布日期:2007-10-24
通讯作者: 司国民

Effect of the Shenqi Jiedu decoction on chronic renal failure: an experimental study

LI Yun, SI Guo-min， ZHANG Yun

Department of Traditional Chinese Medicine, Shandong Provincal Hospital, Shandong University, Jinan 250021, Shandong, China

Received:2007-03-05 Revised:1900-01-01 Online:2007-10-24 Published:2007-10-24
Contact: SI Guo-min

摘要/Abstract

摘要： 目的：验证参芪解毒汤治疗慢性肾功能衰竭（CRF）的疗效。方法：采用腺嘌呤制作大鼠CRF模型，将其分为正常组、模型组、科索亚组及参芪解毒汤高、低剂量组，治疗8周后，测量各组血肌酐(SCr)、尿素氮(BUN)、血清白蛋白（ALB）、甘油三脂(TG)、胆固醇（CHO）、血清瘦素（Leptin）水平，并对大鼠肾脏组织进行病理观察检测转化生长因子β1(TGF-β1)在肾组织的表达。结果：参芪解毒汤高、低剂量组，科索亚组SCr、BUN、Leptin水平均低于模型组，ALB高于模型组（P＜0.05）。病理结果表明，各用药组大鼠的肾组织病理损伤要明显轻于模型组，高剂量组损伤最轻。各用药组TGF-β1在肾组织的表达均明显低于模型组（P＜0.05）。结论：参芪解毒汤可有效降低CRF大鼠SCr、BUN、Leptin水平，升高ALB水平，具有减轻大鼠肾组织的损伤、减少TGF-β1在肾组织的表达、延缓CRF进展的作用。

关键词: 大鼠, Wistar , 转化生长因子, 瘦素, 参芪解毒汤, 慢性肾功能衰竭

Abstract: Objective： To investigate the effects of the Shenqi Jiedu decoction on chronic renal failure(CRF). Methods: Rat models of CRF were established by feeding Adenine. All the rats were randomly divided into five groups: the normal group, the model group, the high dose Shenqi Jiedu decoction group, the low dose Shenqi Jiedu decoction group and the losartan group. After 8 weeks, levels of serum creatinine (SCr), blood urea nitrogen(BUN), plasma albumin(ALB), triglyceride(TG), cholesterol(CHO), Leptin were determined. In addition, the results of pathology were found and the expression of TGF-β1 was determined. Results： Compared with the model group, levels of SCr and BUN in the Shenqi Jiedu decoction groups and the losartan group were decreased while level of ALB was increased (P＜0.05). Pathological results of the Shenqi Jiedu decoction groups and the losartan group were better than those of the model group, and those of the high dose Shenqi Jiedu decoction group were the best. Compared with the model group, expression of TGF-β1 in the Shenqi Jiedu decoction groups and the losartan group were decreased. Conclusions: Shenqi Jiedu decoction can efficiently decrease the SCr, BUN, and Leptin levels and increase the ALB level, reduces the pathological injury and the TGF-β1 expression, and postpones the aggravation of the renal function.

Key words: Chronic renal failure, Shenqi Jiedu decoction, transforming growth factor, Leptin, Rats, Wistar

中图分类号:

R692.5

李云,司国民,张芸. 参芪解毒汤治疗慢性肾功能衰竭的实验研究[J]. 山东大学学报(医学版), 2007, 45(10): 1016-1019.

LI Yun,SI Guo-min,ZHANG Yun. Effect of the Shenqi Jiedu decoction on chronic renal failure: an experimental study[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(10): 1016-1019.

参考文献

相关文章 15

[1]	吴逸南葛志明李方贺红姜虹张运. 自发性高血压大鼠肾脏血管紧张素转换酶2的表达[J]. 山东大学学报(医学版), 2209, 47(6): 5-.
[2]	祝林胡三元张光永丁祥就. 前列腺素E2对阻塞性黄疸大鼠小肠粘膜形态的保护作用[J]. 山东大学学报(医学版), 2209, 47(6): 12-.
[3]	孙涛张道来谢珊珊王玉卓冯玉新辛华. 酒精对原代培养的神经前体细胞间隙连接蛋白43表达的影响[J]. 山东大学学报(医学版), 2209, 47(6): 20-.
[4]	张道来孙涛谢珊珊王玉卓赵玲冯玉新辛华. 体外原代培养胎鼠大脑皮层神经元NMDAR1亚基表达的发育性变化[J]. 山东大学学报(医学版), 2209, 47(6): 28-32.
[5]	张莹王宏伟王慧陈福琴. Graves病复发患者外周血中转化生长因子β1水平的变化[J]. 山东大学学报(医学版), 2209, 47(6): 80-.
[6]	贾魁,李治国,程翠婷,李志娟,刘瑞卿. 银杏叶片联合曲美他嗪治疗老年慢性心力衰竭的效果及机制[J]. 山东大学学报 (医学版), 2025, 63(6): 19-26.
[7]	赵子辉,王旭阳,张鹏,方宁宁,石端博,杨帆,杨晓玫,吴剑波. 经膈肌穿刺法快速准确评估大鼠肺动脉高压[J]. 山东大学学报 (医学版), 2024, 62(2): 20-28.
[8]	祁少俊,唐延金,张正铎,吴虹,张佳程,秦川,刘锐,高希宝. 补充多种微量元素对高糖饮食大鼠的保护作用[J]. 山东大学学报 (医学版), 2023, 61(7): 19-26.
[9]	杨元凤,熊高才,黎豫川,罗玉玲,张敬杰. 鹿苓安肾颗粒对慢性肾功能衰竭大鼠炎症反应及细胞凋亡的影响[J]. 山东大学学报 (医学版), 2023, 61(10): 9-16.
[10]	张秉芬,周胜红,王哲. 延龄草皂苷通过抑制TGF-β/Smad3与Wnt/β-catenin信号通路改善大鼠肺纤维化[J]. 山东大学学报 (医学版), 2022, 60(8): 23-29.
[11]	虎娜,孙苗,邢莎莎,许丹霞,海小明,马玲,杨丽,勉昱琛,何瑞,陈冬梅,马会明. 月见草油抵抗多囊卵巢综合征大鼠卵巢氧化应激[J]. 山东大学学报 (医学版), 2022, 60(5): 22-30.
[12]	李鸿皓,于晶,陈亚丽,郭守刚. 20例NMOSD患者CD4⁺CD25⁺FoxP3⁺调节性T细胞数量和FoxP3 mRNA的表达水平[J]. 山东大学学报 (医学版), 2022, 60(4): 50-54.
[13]	张正铎,吴虹,祁少俊,唐延金,高希宝. 口服5-甲基四氢叶酸对大鼠阿尔茨海默病的预防作用[J]. 山东大学学报 (医学版), 2022, 60(3): 13-23.
[14]	赵慧文,许琳,单姗,赵秀兰. 牛磺酸对1-溴丙烷致大鼠认知功能障碍的保护作用[J]. 山东大学学报 (医学版), 2022, 60(2): 14-21.
[15]	高燕,朱庆颖,栾明亚,刘科卫. 托伐普坦联合达格列净对心衰大鼠心肌纤维化的影响[J]. 山东大学学报 (医学版), 2022, 60(12): 13-18.

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed