微生物药物研究开发现状与思考

doi:10.6040/j.issn.1671-7554.0.2021.0963

摘要/Abstract

摘要： 微生物来源的药物在抗感染、抗肿瘤、免疫抑制和代谢调节等疾病领域发挥着重要作用。抗生素的长期不当使用导致了耐药细菌的产生和蔓延,给公共卫生和安全健康带来了全球性的挑战,寻找新型的抗生素已迫在眉睫。如何从微生物中发掘化学结构和作用机制新颖的新药以对抗愈发严峻的细菌耐药性,已成为当今微生物药物研发面临的新挑战。论文对微生物药物研发历史进行了回顾,并对截至2019年9月在欧美等发达国家上市的微生物药物的数量、产生菌来源和临床适应证进行了归纳总结。最后,针对创新微生物药物研发的迫切性,对微生物药物研发新策略进行了展望。

关键词: 微生物药物, 抗生素, 耐药性, 药物研发策略

Abstract: Microbial drugs play important roles in a panel of therapeutic areas, such as anti-infection, anti-cancer, immunosuppression and metabolic disorder. The long-term abuse of antibiotics has led to the emergence and widespread of drug-resistant bacteria, bringing unprecedented challenges worldwide to the safe and healthy development of public health. Therefore, there is an urgent need for research and development of novel antibiotics. How to discover new drugs with novel chemical structure and mechanism of action from microorganisms to combat the increasingly severe bacterial resistance has become a new challenge for the research and development of microbial drugs. In this review, we gave an overview of the history of microbial drug discovery. The number, producer and indication of the microorganism-derived clinic drugs approved by developed countries, between 1940 and 2019 were also summarized. In addition, due to the urgent need for novel microbial drugs, new strategies for microbiological drug research and development were summarized.

Key words: Microbial drugs, Antibiotics, Drug resistance, Strategies for drug research and development

中图分类号:

R574

鞠建华,杨镇业,李青连,韩亚楠,李艳青,乔伊君,杨虎,张华然. 微生物药物研究开发现状与思考[J]. 山东大学学报 (医学版), 2021, 59(9): 43-50.

JU Jianhua, YANG Zhenye, LI Qinglian, HAN Yanan, LI Yanqing, QIAO Yijun, YANG Hu, ZHANG Huaran. Advances on drugs derived from microbial sources and future perspectives[J]. Journal of Shandong University (Health Sciences), 2021, 59(9): 43-50.

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