组织定居性记忆T细胞在肾脏中的维持与作用

doi:10.6040/j.issn.1671-7554.0.2021.0874

摘要/Abstract

摘要： 组织定居性记忆T细胞(T_RM)是新近发现的一类不参与体循环,驻留在器官的T淋巴细胞。T_RM具有独特的分化调控机制和免疫调节功能,在多种疾病的发生发展中发挥重要作用,有望成为新的治疗靶点。有研究发现T_RM存在于肾脏中,因此本文将围绕T_RM在肾脏中的形成、表型、维持和作用等方面,综述T_RM在肾脏中的最新研究进展。

关键词: 组织定居性记忆T细胞, 肾脏, 免疫微环境

Abstract: Tissue resident memory T cells (T-RM), a recently discovered type of T lymphocytes, do not participate in systemic circulation but reside in organs. T-RM possess a unique differentiation regulation mechanism and contribute to immunomodulatory effect. They play an important role in the occurrence and development of many kinds of diseases and are expected to become a new therapeutic target. T-RM have also been found in the kidney. This review will focus on the formation, biological characteristics and maintenance of T-RM in the kidney and the role of T-RMin kidney diseases.

中图分类号:

R692

易凡,李亮. 组织定居性记忆T细胞在肾脏中的维持与作用[J]. 山东大学学报 (医学版), 2021, 59(9): 15-21.

YI Fan, LI Liang. Maintenance and function of tissue resident memory T cells in the kidney[J]. Journal of Shandong University (Health Sciences), 2021, 59(9): 15-21.

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