口服益生菌对早产儿消化道及免疫功能的影响

山东大学学报(医学版)

口服益生菌对早产儿消化道及免疫功能的影响

张凤娟，孙正芸，程蓓蕾

山东大学附属省立医院儿科，济南 250021

收稿日期:2008-01-20 修回日期:1900-01-01 出版日期:2008-11-16 发布日期:2008-11-16
通讯作者: 孙正芸

Effects of probiotics supplementation on intestinal symptoms and immunity of preterm infants

ZHANG Feng-juan， SUN Zheng-yun, CHENG Bei-lei

Department of Pediatrics, Provincial Hospital Affiliated to Shandong University, Jinan 250021， China

Received:2008-01-20 Revised:1900-01-01 Online:2008-11-16 Published:2008-11-16
Contact: SUN Zheng-yun

摘要/Abstract

摘要： 目的探讨口服益生菌对早产儿消化道及免疫功能的影响。方法将50例住院早产儿随机分为实验组和对照组，实验组给予口服益生菌14?d，观察临床指标和外周血相关免疫学指标。结果实验组早产儿住院期间温盐水灌肠次数较对照组明显减少（P＜0.05）,而两组腹泻发生率差异无统计学意义（P＞0.05）。实验组CD4+T细胞比例和CD4+/CD8+数值高于对照组（P＜0.05），但CD3+及CD8+T细胞比例较对照组改变无统计学意义（P＞0.05）；实验组IgM水平较对照组增加（P＜0.05），IgG含量改变无统计学意义（P＞0.05）；实验组IL4水平高于对照组（P＜0.05），但两组IFN-γ水平及IFN-γ/ IL-4数值差异无统计学意义（P＞0.05）。结论口服益生菌可以改善早产儿消化道症状,明显影响早产儿机体免疫功能的成熟和发展

关键词: 免疫功能, 小于胎龄, 肠道, 婴儿, 益生菌

Abstract: To investigate the effects of probiotics supplementation on intestinal symptoms and immunity of preterm infants. MethodsFifty preterm infants born and hospitalized in the neonatal intensive care unit of our Hospital from June 2007 to December 2007 were randomly divided into the control group and the probiotic group. The probiotic group received probiotics on day 0 to 14 after birth. Intestinal symptoms were observed during hospitalization and blood samples were collected on day 14 to 16 after birth. ResultsThe number of warm brine enema of the probiotic group was lower than that of the control group ［(0.36±0.70) vs (0.92±1.12), P＜0.05］. The proportion of CD4+ T lymphocytes and the ratio of CD4+/CD8+ were increased in the probiotic group, but the proportions of CD3+ and CD8+ T lymphocytes were not statistically changed in the probiotic group. The levels of immunoglobulin M and interlukine4 were increased in the probiotic group, but the level of IFNγand the ratio of IFNγ/ IL4 were not statistically changed in the probiotic group. ConclusionProbiotics could improve intestinal symptoms of preterm infants and have an obvious effect on their immunity.

Key words: Probiotics, Infant, small for gestational, Intestines, Immunity

中图分类号:

R722

张凤娟,孙正芸,程蓓蕾. 口服益生菌对早产儿消化道及免疫功能的影响[J]. 山东大学学报(医学版), 2008, 46(11): 1069-1071.

ZHANG Feng-juan,SUN Zheng-yun,CHENG Bei-lei. Effects of probiotics supplementation on intestinal symptoms and immunity of preterm infants[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(11): 1069-1071.

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