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山东大学学报（医学版） ›› 2016, Vol. 54 ›› Issue (5): 45-49.doi: 10.6040/j.issn.1671-7554.0.2016.020

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ER、PR在妊娠期子宫肌瘤组织中的表达及意义

刘冉1,陶国伟2,甄军晖3,罗霞1,千日成4   

  1. 1.山东大学齐鲁医院妇产科, 山东 济南 250012;2.山东大学齐鲁医院超声科, 山东 济南 250012;3.山东大学齐鲁医院病理科, 山东 济南 250012;4.南京医科大学生殖医学国家重点实验室, 江苏 南京 210029
  • 收稿日期:2016-01-06 出版日期:2016-05-16 发布日期:2016-05-16
  • 通讯作者: 罗霞. E-mail:luoxia0311@163.com E-mail:luoxia0311@163.com
  • 基金资助:
    生殖医学国家重点实验室开放基金(SKLRM-KF-1303)

Expression and significance of ER and PR in fibroids and myometrium during pregnancy

LIU Ran1, TAO Guowei2, ZHEN Junhui3, LUO Xia1, QIAN Richeng4   

  1. 1. Department of Obstetrics and Gynecology;
    2. Department of Ultrasonography;
    3. Department of Pathology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    4. State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, Jiangsu, China
  • Received:2016-01-06 Online:2016-05-16 Published:2016-05-16

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摘要： 目的 探讨雌激素受体(ER)、孕激素受体(PR)在妊娠期子宫肌瘤组织中的表达及意义。 方法 (1)随机选取9例妊娠期患者的子宫肌瘤(A组)及相应的正常子宫平滑肌组织(B组)、12例非妊娠期患者的子宫肌瘤(C组)及相应的正常子宫平滑肌组织(D组),应用免疫组化SP法分别检测ER、PR在4种组织中的表达。(2)随机选择110例妊娠合并子宫肌瘤的孕妇作为研究对象,通过彩色超声检查结果统计子宫肌瘤在妊娠早期(妊娠13周以内)、妊娠中期(妊娠16~23周)和妊娠晚期(妊娠37~40周)的大小。 结果 (1)ER在A组与B组中表达均为阴性,PR在A组中的表达水平明显高于B组(P=0.033)。ER、PR在A组中的表达水平均明显低于C组(P=0.000; P=0.001);(2)妊娠早、中、晚期子宫肌瘤大小差异无统计学意义(P=0.741),但妊娠中、晚期与妊娠早期相比,子宫肌瘤有增大趋势,妊娠晚期与妊娠中期相比,子宫肌瘤有缩小趋势。 结论 ER、PR可能在妊娠期子宫肌瘤的生长中发挥重要作用,而ER缺失是否与妊娠期高雌、孕激素状态下子宫肌瘤生长缓慢有关值得进一步探讨。

关键词: 妊娠, 子宫肌瘤, 雌激素受体, 孕激素受体

Abstract: Objective To explore the expression and significance of ER and PR in fibroids and myometrium during pregnancy. Methods (1) We collected 9 pregnant womens fibroids(group A)and myometrium(group B), and 12 non-pregnant womens fibroids(group C)and myometrium(group D). The expressions of ER and PR in these tissues were detected with immunohistochemistry. (2) We selected 110 pregnant women with fibroids as the research objects, and recorded the sizes of fibroids through ultrasonic reports in early pregnancy(less than 13 weeks), mid pregnancy(16 to 23 weeks gestation)and late pregnancy(37 to 40 weeks gestation). Results (1) The expressions of ER in group A and B were negative. The expression of PR in group A was significantly higher than that in group B(P=0.033). The expressions of ER and PR in group A were significantly lower than those in group C(P=0.000, P=0.001). (2) There was no significant difference in the sizes of fibroids between early mid and late pregnancy(P=0.741). But fibroids had an 山 东 大 学 学 报 (医 学 版)54卷5期 -刘冉,等.ER、PR在妊娠期子宫肌瘤组织中的表达及意义 \=-increasing trend in early and mid pregnancy and had a decreasing trend in late pregnancy. Conclusion ER and PR may play an important role in the growth of fibroids during pregnancy. However, whether ER deletion is related to the slow growth of fibroids with high estrogen and progesterone during pregnancy still remains unclear.

Key words: Progesterone receptor, Pregnancy, Uterine fibroids, Estrogen receptor

中图分类号: 

  • R714.2
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