精神分裂症患者青少年亲属生态学执行功能特征及其与侵害的关系

doi:10.6040/j.issn.1671-7554.0.2014.298

摘要/Abstract

摘要： 目的探讨精神分裂症患者青少年亲属生态学执行功能特征,以及是否存在特定的侵害类型与该人群执行功能改变相关联.方法选取104名精神分裂症患者的青少年子女或同胞作为亲属组和193名正常青少年作为对照组,采用执行功能行为评定量表自评版(BRIEF-SR)和青少年侵害问卷自评版(JVQ)分别评估被试的生态学执行功能和侵害发生情况.结果亲属组在转换和任务完成因子上的得分高于对照组(均P<0.05);在亲属组中,经历一般侵害的青少年在计划/组织和任务完成因子上得分高于未经历一般侵害的被试(均P<0.05),经历儿童虐待的被试在抑制、情绪控制及材料组织因子上得分高于未经历儿童虐待的被试(均P<0.05).结论精神分裂症患者的青少年亲属在转换和任务完成等执行功能成分上存在缺陷,一般侵害和儿童虐待与该人群执行功能改变有关.

关键词: 执行功能, 精神分裂症, 一级亲属, 青少年, 侵害

Abstract: Objective To investigate specific executive deficits in the real-life environment among adolescent relatives of schizophrenia patients and to explore the effect of specific victimization types on the deficits. Methods The study included 104 non-affected adolescent descendants and siblings of schizophrenia patients in the relative group and 193 healthy adolescents in the healthy control group, all aged between 9 and 20 years. All participants completed the Behavior Rating Inventory of Executive Function-Self Report Version (BRIEF-SR) and Juvenile Victimization Questionnaire, Child Self-report Version (JVQ). Results The multivariate analysis revealed that the relative group reported more difficulties on the shift and task completion scale than controls (P<0.05). Significant main effects were detected for conventional crime on the plan/organize and task completion scale (P<0.05) and for child maltreatment on the inhibit, emotional control, monitor, working memory and organization of material scale (P<0.05). The univariate analysis revealed that in the relative group, adolescents who had experienced conventional crime reported higher scores on the plan/organize and task completion scale compared with those without conventional crime (P<0.05); adolescents with child maltreatment had higher scores on the Inhibit, emotional control, and organization of material scale than those without child maltreatment (P<0.05). For the healthy controls, adolescents with child maltreatment showed poorer scores on the Working Memory scale than those without maltreatment (P<0.05). Conclusion Our resultssuggest certain impaired aspects of executive functioning in real-life situations among adolescent relatives of schizophrenia patients. Conventional crime and child maltreatment may be associated with executive dysfunction in the adolescent relatives.

Key words: Schizophrenia, First-degree relatives, Executive function, Victimization, Adolescents

中图分类号:

R749.3

李阳, 曹枫林, 钟耕坤, 林萍珍, 梁鑫浩. 精神分裂症患者青少年亲属生态学执行功能特征及其与侵害的关系[J]. 山东大学学报（医学版）, 2014, 52(11): 86-91.

LI Yang, CAO Fenglin, ZHONG Gengkun, LIN Pingzhen, LIANG Xinhao. Ecological executive function in adolescent relatives of schizophrenia patients and its relationship with victimization[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(11): 86-91.

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