Journal of Shandong University (Health Sciences) ›› 2023, Vol. 61 ›› Issue (5): 90-95.doi: 10.6040/j.issn.1671-7554.0.2023.0027

• 公共卫生与管理学 • Previous Articles    

Epidemic and whole genome characteristics of coxsackievirus A16 in Jining in 2021

WANG Shan1,2, JIAO Boyan2, FENG Qiang3, DUAN Yanhua2, WEN Hongling1   

  1. 1. School of Public Health, Shandong University, Jinan 250012, Shandong, China;
    2. Jining Center for Disease Control and Prevention, Jining 272000, Shandong, China;
    3. Renchen Center for Disease Control and Prevention, Jining 272000, Shandong, China
  • Published:2023-05-15

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Abstract: Objective To analyze the epidemic and whole genome characteristics of coxsackievirus A16(CV-A16)in Jining in 2021. Methods A total of 513 stool samples were collected from patients with hand, foot and mouth disease(HFMD), which were then underwent nucleic acid detection of CV-A16 and virus isolation. Whole genome sequencing and bioinformatics analysis were performed on 4 CV-A16 strains. Results Altogether 36 cases were positive for CV-A16, with a positive rate of 7.02%(36/513). The positive rate was the highest from July to September. The 4 strains were distributed in B1a and B1b branches. Compared with prototype strain G-10(CAU05876), the 4 strains had homology of nucleotide and amino acid of 77.5%-78.0% and 94.7%-94.9%, respectively. There were multiple amino acid changes in the encoded proteins of the 4 strains. Conclusion CV-A16 was one of the main pathogens of HFMD in Jining in 2021, including B1a and B1b subtypes. The surveillance of the disease should be strengthened.

Key words: Hand, foot and mouth disease, Coxsackievirus A16, Whole genome sequencing

CLC Number: 

  • R373.2
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