Journal of Shandong University (Health Sciences) ›› 2023, Vol. 61 ›› Issue (1): 32-37.doi: 10.6040/j.issn.1671-7554.0.2022.1074

• 临床医学 • Previous Articles    

Comparison of cerebrospinal fluid detection in 53 patients with neuromyelitis optica spectrum disorder and 11 patients with multiple sclerosis

HOU Shaojin, WANG Yunfeng, CAO Lili, LIU Xuewu, ZHAO Xiuhe, WANG Shengjun   

  1. Department of Neurology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Published:2023-01-10

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Abstract: Objective To investigate the cytological, biochemical and oligoclonal band results of cerebrospinal fluid(CSF)between patients with aquaporin-4 immunoglobulin(AQP4-IgG)positive neuromyelitis optica spectrum disorder(NMOSD)and multiple sclerosis(MS). Methods A total of 53 AQP4-IgG seropositive NMOSD patients(NMOSD group)and 11 MS patients(MS group)who met the inclusion criteria were selected. Lumbar puncture was completed within 48 hours after admission and CSF cytology, biochemistry and oligoclonal band detection were performed to compare the results. Results There was no significant difference in sex ratio between the two groups(P=0.665), while the NMOSD group had significantly older age than the MS group(P=0.043). Although there was no significant difference in the proportion of increased CSF white cell count between the two groups(P=0.074), the NMOSD group had higher count than the MS group(P=0.028). The lactate level in NMOSD group was significantly higher than that in MS group(P=0.041). No statistical differences were found in the other variables between the two groups(P>0.05). According to the clinical and imaging results, the NMOSD patients were divided into "myelitis", "optic neuritis" and "brain lesion" subgroups, whose white cell count increased by 81.3%(26/32), 60%(3/5)and 50%(3/6), respectively. Monocytes and lymphocytes were present in all NMOSD samples. Neutrophils were detected in only 3 NMOSD patients and no neutrophils were observed in MS patients. In addition, CSF white cell count was significantly correlated with the spinal cord lesion length in NMOSD myelitis patients, while CSF total protein, IgG/M/A and lactate levels were not significantly correlated with the spinal cord lesion length. Conclusion The white cell count and lactate levels in CSF of AQP4-IgG seropositive NMOSD patients are higher than those of MS patients. The white cell count in CSF is correlated with spinal cord injury.

Key words: Neuromyelitis optica spectrum disorder, Multiple sclerosis, Cerebrospinal fluid, White cell count, Lactate

CLC Number: 

  • R741
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