Journal of Shandong University (Health Sciences) ›› 2023, Vol. 61 ›› Issue (1): 45-50.doi: 10.6040/j.issn.1671-7554.0.2022.1013

• 临床医学 • Previous Articles    

Comparison of the euploidy rate of PGT-A tested embryos between long GnRH agonist and GnRH antagonist protocols

YU Wenhao, ZHANG Qian, SUN Mei, LI Hongchang, ZHU Yueting, JIANG Wenjie, YAN Junhao   

  1. Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University &
    Key Laboratory of Reproductive Endocrinology of Ministry of Education &
    National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan 250012, Shandong, China
  • Published:2023-01-10

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Abstract: Objective To investigate the use of gonadotropin-releasing hormone(GnRH)analog on embryonic euploidy rate as well as clinical pregnancy rate(CPR)in preimplantation genetic testing for aneuploidy(PGT-A)cycles. Methods From Jan. 2017 to Oct. 2020, young women with good ovarian reserve who underwent PGT-A cycles were selected, including 359 cycles and 1,475 blastocysts. The subjects were divided into the antagonist group(n=157)and agonist group(n=202). The baseline parameters, ovulation induction and ovulation cycle parameters of the two groups were determined with univariate analysis, and parameters with statistically significant differences were included in multivariate Logistic regression analysis. The primary parameter was the euploidy rate, and secondary parameter was CPR. Results No statistically significant differences were found in the good-quality blastocysts rate from meiosis Ⅱ(MⅡ)oocytes(41.4% vs 42.9%, P=0.335), embryonic euploidy rate(56.1% vs 52.6%, P=0.171), and CPR(69.2% vs 63.2%, P=0.289)of cryo-thawed embryo transfer(CET). After female age, body mass index(BMI), number of MⅡ oocytes, polycystic ovarian syndrome(PCOS)diagnosis, dosages of gonadotropins(Gn)and human chorionic gonadotropin(HCG)were adjusted, the selection of GnRH analog to achieve pituitary suppression did not affect the embryonic euploidy rate or CPR(P>0.05). For young patients with good ovarian reserve, there was a low statistically significant association between the number of oocytes retrieved and embryonic euploidy rate(P=0.04, OR=1.02, 95%CI: 1.00-1.04). Conclusion Stimulation with long GnRH agonist protocol and GnRH antagonist protocol results in a fairly similar embryonic euploidy rate and clinical pregnancy rate for young patients with ideal ovarian reserve. The findings support the flexible use of GnRH analogs to optimize treatment for this group of patients.

Key words: Embryonic euploidy rate, Ovarian stimulation protocol, Preimplantation genetic testing, Gonadotropin-releasing hormone analog, Cryo-thawed embryo transfer

CLC Number: 

  • R715.5
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