Abstract: Objective: To observe the changes of bowel sensory-motor function after shigella flexneri infection and the effects of various treatment for bowel function in rats, and therefore to provide guidance for preventing PI-IBS. Methods: Forty female Wistar rats weighted 170～180g were divided into normal control and model, antibiotics-treatment, probiotics-treatment and combination treatment groups. The 32 rats in the latter 4 groups were firstly infected with shigella flexneri by gavage to establish the model of acute infectious enteritis, and the normal controls were treated with 0.9% saline. Secondly in 16～22 days after bowel inflammation, the perceptual threshold was detected and the contraction of enteric smooth muscle was measured in vitro to observe the changes of bowel sensitivity and motility and the same time the histological changes were observed. Results: No obvious histological changes were found in different groups. The perceptual threshold decreased and the tension integral of enteric smooth muscle increased greatly in model group, antibioticstreatment and probioticstreatment groups(P<0.05), while that of combination treatment group had no difference from normal control. Conclusion: Shigella flexneri infection can lead to bowel sensorymotor disorder which prolongs for a period of time after inflammation diminishes. Treatment with antibiotics or probiotics singlely can not normalize the functional disturbance, but combination treatment can.

Key words: Shigella flexneri, Bowel function, Antibiotics, Probiotics