您的位置：山东大学 -> 科技期刊社 -> 《山东大学学报（医学版）》

山东大学学报 (医学版) ›› 2020, Vol. 1 ›› Issue (9): 77-82.doi: 10.6040/j.issn.1671-7554.0.2020.0366

• • 上一篇    下一篇

青少年不宁腿综合征与自杀行为的关系

安迪,汪心婷,刘珍珍,贾存显   

  1. 山东大学齐鲁医学院公共卫生学院流行病学系 &山东大学自杀预防研究中心, 山东 济南 250012
  • 出版日期:2020-09-10 发布日期:2020-08-30
  • 通讯作者: 贾存显. E-mail:jiacunxian@sdu.edu.cn
  • 基金资助:
    国家自然科学基金(81573233);山东大学公共卫生学院三级学科基础建设项目(2017-08)

Association between restless legs syndrome and suicidal behaviors among adolescents

AN Di, WANG Xinting, LIU Zhenzhen, JIA Cunxian   

  1. Department of Epidemiology, School of Public Health, Cheeloo College of Medicine &
    Center for Suicide Prevention Research, Shandong University, Jinan 250012, Shandong, China
  • Online:2020-09-10 Published:2020-08-30

PDF (PC)

475

摘要： 目的 探究青少年不宁腿综合征和自杀行为间的关系。 方法 在山东省三县(市)采用方便整群抽样的方式共选取5所初中和3所高中作为目标学校,调查对象为来自目标学校的7~11年级学生,发放问卷收集相关资料,包括研究对象的一般人口学信息、不宁腿综合征、自杀行为、抑郁和失眠等信息,共收集有效调查问卷11 831份。采用多因素Logistic回归模型分析不宁腿综合征和自杀行为的关系。 结果 11 831名研究对象的平均年龄为(14.97±1.46)岁,49.1%是女性。不宁腿综合征组的自杀行为(33.3% vs 21.6%,P<0.05)、自杀意念(29.7% vs 19.5%,P<0.05)、自杀计划(15.2% vs 9.0%,P<0.05)和自杀未遂(7.0% vs 3.6%,P<0.05)的报告率均高于非不宁腿综合征组。调整其他潜在混杂因素后,多因素Logistic回归分析显示不宁腿综合征与自杀行为(OR=1.36, 95%CI=1.18~1.57)、自杀意念(OR=1.25, 95%CI=1.08~1.46)、自杀计划(OR=1.26, 95%CI=1.04~1.52)和自杀未遂(OR=1.35, 95%CI=1.03~1.76)的关联均具有统计学意义。 结论 在青少年中,不宁腿综合征和自杀行为间存在关联。

关键词: 青少年, 不宁腿综合征, 自杀行为

Abstract: Objective To explore the association between restless legs syndrome(RLS)and suicidal behaviors in a large sample of Chinese adolescents. Methods A total of 11 831 adolescents were included in the analysis. The 7-11 graders were sampled from 5 middle schools and 3 high schools in 3 counties of Shandong Province, China. A self-administrated structured questionnaire was used to collect information about demographics, RLS, suicidal behaviors, depression and insomnia. Logistic regression analyses were performed to examine the association between RLS and suicidal behaviors. Results Of the 11 831 participants, the average age was(14.97±1.46)years and 49.1% were girls. The prevalence of suicidal behaviors(33.3% vs 21.6%, P<0.05), suicidal ideation(29.7% vs 19.5%, P<0.05), suicide plan(15.2% vs 9.0%, P<0.05)and suicide attempt(7.0% vs 3.6%, P<0.05)were higher in adolescents with RLS than in those without. Multivariate Logistic regressions showed that RLS was associated with suicidal behaviors(OR=1.36, 95%CI=1.18-1.57), suicidal ideation(OR=1.25, 95%CI=1.08-1.46), suicide plan(OR=1.26, 95%CI=1.04-1.52), and suicide attempt(OR=1.35, 95%CI=1.03-1.76). Conclusion RLS is associated with suicidal behaviors among adolescents.

Key words: Adolescents, Restless legs syndrome, Suicidal behaviors

中图分类号: 

  • B845
[1] Hawton K, Saunders KE, O'Connor RC. Self-harm and suicide in adolescents[J]. Lancet, 2012, 379(9834):2373-2382.
[2] 谢杨. 青少年自杀行为及影响因素研究[J]. 首都公共卫生, 2017, 11(3): 115-117. XIE Yang. Prevalence and influencing factors of suicide behaviors among adolescents[J]. Capital Journal of Public Health, 2017, 11(3): 115-117.
[3] Klonsky ED, May AM, Saffer BY. Suicide, suicide attempts, and suicidal ideation[J]. Annu Rev Clin Psychol, 2016, 12(1): 307-330.
[4] Marty MA, Segal DL. DSM-5: diagnostic and statistical manual of mental Disorders[M]. Arlington, VA: American Psychiatric Association, 2013: 410-413.
[5] 刘春燕, 丁岩, 侯月, 等. 中国不宁腿综合征研究进展:中国学者海外报道[J]. 中国现代神经疾病杂志, 2017, 17(9): 639-643. LIU Chunyan, DING Yan, HOU Yue, et al. Research progress of restless legs syndrome in China: Chinese scholars reports published abroad[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2017, 17(9): 639-643.
[6] Ohayon MM, O Hara R, Vitiello MV. Epidemiology of restless legs syndrome: A synthesis of the literature[J]. Sleep Med Rev, 2012, 16(4): 283-295.
[7] Winkelmann J, Prager M, Lieb R, et al. “Anxietas Tibiarum”: depression and anxiety disorders in patients with restless legs syndrome[J]. J Neurol, 2005, 252(1): 67-71.
[8] Liu XC, Chen H, Liu ZZ, et al. Prevalence of suicidal behaviour and associated factors in a large sample of Chinese adolescents[J]. Epidemiol Psych Sci, 2019, 28(3): 280-289.
[9] Liu ZZ, Chen H, Bo QG, et al. Psychological and behavioral characteristics of suicide attempts and non-suicidal self-injury in Chinese adolescents[J]. J Affect Disord, 2018, 226: 287-293. doi: 10.1016/j.jad.2017.10.010.
[10] Liu B, Wang X, Liu Z, et al. Stressful life events, insomnia and suicidality in a large sample of Chinese adolescents[J]. J Affect Disord, 2019, 249: 404-409. doi: 10.1016/j.jad.2019.02.047.
[11] Allen RP, Picchietti D, Hening WA, et al. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health[J]. Sleep Med, 2003, 4(2): 101-119.
[12] Radloff LS. The CES-D Scale A Self-Report Depression Scale for Research in the General Population[J]. Appl Psych Meas, 1977, 1(3): 385-401.
[13] Stockings E, Degenhardt L, Yong YL, et al. Symptom screening scales for detecting major depressive disorder in children and adolescents: A systematic review and meta-analysis of reliability, validity and diagnostic utility[J]. J Affect Disord, 2015, 174: 447-463. doi: 10.1016/j.jad.2014.11.061.
[14] 刘贤臣, 唐茂芹, 胡蕾, 等. 匹兹堡睡眠质量指数的信度和效度研究[J]. 中华精神科杂志, 1996, 29(2): 103-107. LIU Xianchen, TANG Maoqin, HU Lei, et al. Reliability and validity of the Pittsburgh sleep quality index[J]. Chinese Journal of Psychiatry, 1996, 2: 103-107.
[15] Zhuang S, Na M, Winkelman JW, et al. Association of restless legs syndrome with risk of suicide and self-harm[J]. JAMA Network Open, 2019, 2(8): e199966. doi: 10.1001/jamanetworkopen.2019.9966.
[16] Para KS, Chow CA, Nalamada K, et al. Suicidal thought and behavior in individuals with restless legs syndrome[J]. Sleep Med, 2019, 54: 1-7. doi: 10.1016/j.sleep.2018.09.019.
[17] Li Y, Mirzaei F, O'Reilly EJ, et al. Prospective study of restless legs syndrome and risk of depression in women[J]. Am J Epidemiol, 2012, 176(4): 279-288.
[18] Picchietti D, Allen RP, Walters AS, et al. Restless legs syndrome: prevalence and impact in children and adolescents - the Peds REST study[J]. Pediatrics, 2007, 120(2): 253-266.
[19] Pagel JF, Natalie F, Carol K. Adolescent sleep disturbance and school performance: the confounding variable of socioeconomics[J]. J Clin Sleep Med, 2007, 3(1): 19-23.
[20] 邱健, 赵显超, 程金湘, 等. 多巴胺能系统与不宁腿综合征的昼夜节律[J]. 中风与神经疾病杂志, 2019, 36(5): 467-470. QIU Jian, ZHAO Xianchao, CHENG Jinxiang, et al. The circadian rhythm of dopaminergic system and restless leg syndrome[J]. Journal of Apoplexy and Nervous Diseases, 2019, 36(5): 467-470.
[21] Fitzgerald ML, Kassir SA, Underwood MD, et al. Dysregulation of striatal dopamine receptor binding in suicide[J]. Neuropsychopharmacology, 2017, 42(4): 974-982.
[22] Connor JR, Patton SM, Oexle K, et al. Iron and restless legs syndrome: treatment, genetics and pathophysiology[J]. Sleep Med, 2017, 31: 61-70. doi: 10.1016/j.sleep.2016.07.028.
[23] Li X, Allen RP, Earley CJ, et al. Brain iron deficiency in idiopathic restless legs syndrome measured by quantitative magnetic susceptibility at 7 tesla[J]. Sleep Med, 2016, 22: 75-82. doi: 10.1016/j.sleep.2016.05.001.
[24] Li Y, Dai Q, Torres ME, et al. Gender-specific association between iron status and the history of attempted suicide: Implications for gender paradox of suicide behaviors[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2007, 31(7): 1429-1435.
[25] Lin L, Zhang J. Impulsivity, mental disorder, and suicide in rural China[J]. Archives Suicide Res, 2017, 21(1): 73-82.
[1] 况利,徐何雁. 从精准评估到整合干预:儿童青少年心理健康问题诊疗范式的革新与展望[J]. 山东大学学报 (医学版), 2026, 64(3): 10-16.
[2] 樊呈敏,宋静雨,于书彦,毛雪琴. 舒肝解郁胶囊治疗青少年抑郁障碍的研究进展[J]. 山东大学学报 (医学版), 2026, 64(3): 17-23.
[3] 李芳华,刘娜,李晓宇,许殿花,王倩. 儿童青少年抑郁障碍患者服药依从性研究进展[J]. 山东大学学报 (医学版), 2026, 64(3): 24-34.
[4] 方婷婷,胡章捷,禚凤,解欣然,杨楹,孔令华. 青少年网络偏差行为潜在剖面与网络分析——以江西省为例[J]. 山东大学学报 (医学版), 2026, 64(3): 35-44.
[5] 常源,王帆,文颖,陈光辉. 父母心理控制、受欺凌与青少年非自杀性自伤的关系:自我同情的保护作用[J]. 山东大学学报 (医学版), 2026, 64(3): 55-64.
[6] 沈君,周爽,杜苗,蒋颖. 青少年情绪障碍患者及其照顾者病耻感与家庭复原力的关系:基于主客体互倚模型[J]. 山东大学学报 (医学版), 2026, 64(3): 65-77.
[7] 王倩,胡晓婧,王爱青,孙强,孟春燕,李芳华. 儿童青少年抑郁障碍患者非自杀性自伤文献的可视化分析[J]. 山东大学学报 (医学版), 2026, 64(3): 93-107.
[8] 李鑫源,张心之,狄德润,原所茂,刘新宇,王连雷. Cobb角负重位三维自动成像与X线平片的对比分析[J]. 山东大学学报 (医学版), 2026, 64(2): 89-95.
[9] 黄艳,周应芳,彭超. 青少年子宫内膜异位症的管理要点和策略[J]. 山东大学学报 (医学版), 2025, 63(10): 8-12.
[10] 解欣然,禚凤,杨楹,孔令华. 青少年抑郁障碍与多种心理行为问题的网络分析[J]. 山东大学学报 (医学版), 2024, 62(12): 49-58.
[11] 赵心睿, 李静雅, 孔令华, 李丛冉, 韦雨欢, 杨楹. 青少年抑郁障碍与网络成瘾的关系:社交回避和学业挫败感的中介作用[J]. 山东大学学报 (医学版), 2024, 62(12): 65-71.
[12] 李献云,杨甫德. 自杀倾向的认知行为治疗[J]. 山东大学学报 (医学版), 2022, 60(4): 1-9.
[13] 贾存显,刘珍珍. 关注睡眠问题,预防青少年自伤[J]. 山东大学学报 (医学版), 2022, 60(2): 1-7.
[14] 徐小明,孔裔婷,刘川,明英,况利. 青少年和年轻成人自杀预警系统研究进展[J]. 山东大学学报 (医学版), 2022, 60(2): 69-74.
[15] 姚志英,魏艳欣,汪心婷,张杰,贾存显. 农村居民自杀行为暴露与自杀未遂关系的研究[J]. 山东大学学报 (医学版), 2022, 60(1): 86-92.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
版权所有 © 2018 《山东大学学报(医学版)》编辑部　
地址:山东大学科技期刊社（济南市历城区山大南路27号山东大学中心校区明德楼B座721室） 电话: 0531-88366918 E-mail: xbyxb@sdu.edu.cn
本系统由北京玛格泰克科技发展有限公司设计开发