关键词: 蛇毒血凝酶；膀胱冲洗；膀胱灌注；经尿道前列腺电切术；止血

Abstract:

Objective   To evaluate the hemostatic effect of hemocoagulase used in bladder irrigation and intravesical instillation after transurethral resection of the prostate (TURP). Methods   From March 2010 to March 2012, 69 selected patients who underwent TURP were randomly divided into three groups, and all patients were administrated with postoperative continuous bladder irrigation using  NS conventionally. 20 cases in the intravesical instillation group were given postoperative intravesical instillation using 6U hemocoagulase in 60mL NS for 20min, bid for 3d. 23 cases in the bladder irrigation group were given bladder irrigation using 10U hemocoagulase in 100mLNS, bid for 3d. The rest of 26 patients were assigned to the control group with continuous bladder irrigation using normal saline (NS). The bleeding volumes in the 3 days after surgery of the 3 groups were recorded and analyzed by using SPSS16.0 software and the coagulation function and adverse effects were observed. Results   There was no significant difference of patients′ age, prostate volume or operation time among the three groups, additionally, no obvious coagulant function change and complications occurred in the patients of the three groups. Compared with that of the control group, the total bleeding volumes of the postoperative 3 days in the experimental groups of hemocoagulase were significantly reduced (P<0.05). However, for 3 days′ total or each day′s blood bleeding volume, no significant difference was observed between the bladder irrigation group and the intravesical instillation group. Conclusion   Local application of hemocoagulase was effective and safe in reducing postoperative bleeding after TURP.

Key words:  Hemocoagulase; Bladder irrigation; Intravesical instillation; Transurethral resection of the prostate; Hemostasis