B族维生素治疗肾移植受者高同型半胱氨酸血症

山东大学学报(医学版)

B族维生素治疗肾移植受者高同型半胱氨酸血症

赵敬杰¹，刘军莉¹，田川²，张彩³

山东大学第二医院 1. 临床分子生物学实验室； 2. 移植中心，山东济南 250033；3. 山东大学药学院免疫药理与免疫治疗研究所，山东济南 250012

收稿日期:2007-06-12 修回日期:1900-01-01 出版日期:2007-08-24 发布日期:2007-08-24
通讯作者: 张彩

Effect of vitamin B on hyperhomocysteinemia in renal-transplant recipients

ZHAO Jing-jie¹，LIU Jun-li¹，TIAN Chuan²，ZHANG Cai³

1. Laboratory of Clinical Molecular Biology, Second Hospital of Shandong University；2. Transplant Center, Second Hospital of Shandong University；3. Institute of Immuno-pharmacology and Immunotherapy, School of Pharmacy

Received:2007-06-12 Revised:1900-01-01 Online:2007-08-24 Published:2007-08-24
Contact: ZHANG Cai

摘要/Abstract

摘要： 目的：探讨叶酸、维生素B6及B12在治疗肾移植患者高同型半胱氨酸（Hcy）血症中的作用。方法：将195例预接受首次肾移植患者随机分为两组：试验组103例，口服叶酸5mg/d，维生素B6 50mg/d及维生素B12 1mg/d，连续2个月左右；对照组92例则未口服B族维生素。分别于服药治疗前、术前1d、术后1、10、20及30d检测血浆Hcy浓度和血清肌酐水平。结果：试验组血浆Hcy浓度与对照组相比具有统计学意义（P＜0.0001），试验组术后血清肌酐水平下降较快，发生急性排斥反应的比例低于对照组。结论：肾移植患者围手术期适当补充叶酸、维生素B6及B12可降低血浆Hcy浓度，有助于移植肾功能的快速恢复，是减少肾移植并发症及急性排斥反应的重要措施。

Abstract: Objective: To explore the effect of folic acid, Vit B6, and Vit B12 on hyperhomocysteinemia in renal-transplant recipients. Methods: 195 renal-transplant recipients were randomly divided into the vitamin treatment group (group A, n=103, folic acid 5mg/d, vitamin B6 50mg/d, Bl2 1mg/d, totally 2 months) and the control group (group B, n=92)． The plasma Hcy levels were determined before treatment, before operation and 1, 10, 20 and 30 days after operation. Results: The plasma level of Hcy in group B was significantly higher than that in group A before and after operation. The rate of acute rejection was lower in group A than in group B. Conclusion: Vitamin B supplementation can reduce the homocysteine level and the rate of acute rejection for renal-transplant recipients．

Key words: Homocysteine, Vitamins, Kidney transplantation

中图分类号:

R699.2

赵敬杰,刘军莉,田川,张彩 . B族维生素治疗肾移植受者高同型半胱氨酸血症[J]. 山东大学学报(医学版), 2007, 45(8): 771-773.

ZHAO Jing-jie,LIU Jun-li,TIAN Chuan,ZHANG Cai. Effect of vitamin B on hyperhomocysteinemia in renal-transplant recipients[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(8): 771-773.

参考文献

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed

[1]	任巨超, 李明宝, 刘焕银, 房志卿, 闫磊, 徐忠华. 腹腔镜超声在肾部分切除术治疗肾门旁中央型小肾癌中的临床价值[J]. 山东大学学报（医学版）, 2015, 53(3): 77-80.
[2]	刘好田1，李嫚1，于国放2，门同义3，王建宁3，郝淑倩4，曹淑娟1. 超声造影在诊断同种异体移植肾慢性排斥反应中的应用[J]. 山东大学学报(医学版), 2012, 50(8): 108-.