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山东大学学报 (医学版) ›› 2022, Vol. 60 ›› Issue (7): 48-55.doi: 10.6040/j.issn.1671-7554.0.2022.0263

• 子宫腺肌病研究专题 • 上一篇    下一篇

子宫腺肌病动物模型研究进展

王国云,潘臧钰   

  1. 山东省立医院妇科 山东大学医学融合与实践中心, 山东 济南 250021
  • 发布日期:2022-07-27
  • 通讯作者: 王国云. E-mail:wangguoy@sdu.edu.cn
  • 基金资助:
    国家自然科学基金(82071621);山东省科技厅重大基础类项目(ZR2021ZD34)

Research progress of animal models of adenomyosis

WANG Guoyun, PAN Zangyu   

  1. Department of Gynecology, Shandong provincial Hospital;
    Medical Integration and Practice Center, Cheeloo College of Medicine, Shandong University, Jinan 250021, Shandong, China
  • Published:2022-07-27

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摘要： 子宫腺肌病是指子宫内膜(包括腺体和间质)侵入子宫肌层生长产生的病变;主要临床症状包括月经过多、严重痛经和不孕,对患者身心健康造成很大的影响。子宫腺肌病好发于育龄期女性,但因其病因尚不明确,缺乏敏感特异的诊断办法,且治疗手段有限,导致了目前亟需对发病机制、特征性诊断、针对性治疗的深入研究。动物模型的建立及应用对上述问题的解决具有重要意义。目前研究表明子宫腺肌病非人类特有,故有可选择的实验动物,且多种雌性动物的生殖系统与人类女性生殖系统具有相似性,有利于开展机制方面的研究。就子宫腺肌病动物模型建立及应用进行综述。

关键词: 子宫腺肌病, 动物模型, 模型建立, 发病机制, 激素

Abstract: Adenomyosis refers to the pathological changes caused by the invasion of endometrium (including glands and stroma) into the myometrium. The main clinical symptoms include menorrhagia, severe dysmenorrhea and infertility, which have a serious impact on the physical and mental health of patients. Adenomyosis often occurs in women of childbearing age, but its etiology remains unclear. There is still no specific diagnostic method, and the treatment methods are limited. Researches on the pathogenesis, characteristic diagnosis and targeted treatment are urgently needed. The establishment and application of animal models are significant to solve the above problems since many studies have shown that adenomyosis is not unique to humans. The alternative experimental animals have reproductive system similar to that of human women, which is conducive to the study of mechanism. This paper reviews the establishment and application of animal model of adenomyosis.

中图分类号: 

  • R711.74
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