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山东大学学报 (医学版) ›› 2021, Vol. 59 ›› Issue (8): 1-7.doi: 10.6040/j.issn.1671-7554.0.2021.0861

• 生殖免疫的基础与临床研究进展专题 •    下一篇

子宫内膜容受性影响因素的研究进展

陈子江1,2,3,4,*(),颜军昊1,2,3   

  1. 1 山东大学生殖医学研究中心, 山东 济南 250001 Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan 250001, Shandong, China
    2 山东省生殖健康临床医学研究中心, 山东 济南 250001 Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Shandong University, Jinan 250001, Shandong, China
    3 国家辅助生殖与优生工程技术研究中心, 山东 济南 250021 National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan 250021, Shandong, China
    4 上海交通大学医学院附属仁济医院生殖中心, 上海 200127 Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
  • 收稿日期:2021-07-23 出版日期:2021-08-10 发布日期:2021-09-16
  • 通讯作者: 陈子江 E-mail:chenzijiang@hotmail.com
  • 作者简介:陈子江,中国科学院院士,山东大学讲席教授/主任医师、附属生殖医院首席专家,国家辅助生殖与优生工程技术研究中心主任,上海市辅助生殖与优生重点实验室(上海仁济医院)主任。国际生殖学会联盟(IFFS)常务执委和秘书长。从事妇产科学、生殖医学和医学遗传学领域的临床诊疗与科学研究,主持国家重点研发计划、973项目、863计划、国家自然科学基金重点项目等课题;获国家发明奖、国家科技进步奖、全国创新争先奖、何梁何利科技进步奖等;以通讯作者在《NEJM》《Lancet》《Nature》《Cell》等期刊发表SCI论文200余篇
  • 基金资助:
    国家重点研发计划(2016YFC1000604);国家重点研发计划(2016YFC1000604)

Latest research advances on factors that influence endometrial receptivity

Zijiang CHEN1,2,3,4,*(),Junhao YAN1,2,3   

  • Received:2021-07-23 Online:2021-08-10 Published:2021-09-16
  • Contact: Zijiang CHEN E-mail:chenzijiang@hotmail.com

摘要:

子宫内膜容受性,是指子宫内膜对胚胎的接受能力。良好的子宫内膜状态是成功妊娠的关键,而在整个月经周期中仅在种植窗期内膜才拥有良好的容受性。据报道,约有2/3的胚胎植入失败或妊娠丢失归咎于子宫内膜的原因。因此,针对引起不良子宫内膜容受性的因素及具体机制的研究,将有助于及时诊断并有效治疗相关不孕疾病,改善妊娠结局。综述影响子宫内膜容受性的多种因素,以期为深入研究子宫内膜容受性的生理病理机制提供思路。

Abstract:

Good endometrial condition is essential to successful pregnancy. Endometrial receptivity, the capability of endometrium to receive embryo, will improve during the window of implantation in menstruation cycle, indicating the accurate time for implantation. As reported, 2/3 cases on embryo implantation failure or pregnancy loss were attributed to endometrial dysfunction. Evidence based on studies about bad endometrial receptivity and exact mechanism thereof, will provide effective approaches for diagnosis and treatment of these dysfunctions. In this review, we elaborated multiple underlying factors that influence endometrial receptivity, hoping to provide reference for further studies on pathophysiological mechanisms of endometrium in embryo implantation failure or pregnancy loss.

中图分类号: 

  • 子宫内膜容受性
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