山东大学学报 (医学版) ›› 2021, Vol. 59 ›› Issue (6): 16-24.doi: 10.6040/j.issn.1671-7554.0.2021.0295
李敏启1,2,杜娟1,3,杨盼盼1,2,寇雨莹1,2,柳珊珊1,2
LI Minqi1,2, DU Juan1,3, YANG Panpan1,2, KOU Yuying1,2, LIU Shanshan1,2
摘要: 骨质疏松症是一种骨量降低、骨组织微结构破坏、骨脆性增加,导致患者容易出现骨折的全身代谢性疾病。伴随着老龄化社会的到来,骨质疏松目前已成为我国中老年人群的重要健康问题。骨质疏松症的发病因素是多方面的,增龄、衰老造成的器官功能减退是主要因素,而“氧化应激衰老理论”迄今仍然是最有据可循的衰老机制假说。综述将围绕氧化应激与骨形成、氧化应激与骨吸收以及抗氧化剂与骨稳态维持等方面,回顾氧化应激诱导骨质疏松症发生发展的相关研究进展。
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