山东大学学报 (医学版) ›› 2020, Vol. 58 ›› Issue (4): 95-99.doi: 10.6040/j.issn.1671-7554.0.2019.1507
• • 上一篇
高春媛1,刘星亮2,娄展2,刘占矿3,岳秉宏2
GAO Chunyuan1, LIU Xingliang2, LOU Zhan2, LIU Zhankuang3, YUE Binghong2
摘要: 目的 探究轻度脑白质疏松症(LA)患者认知能力及大脑中动脉搏动指数(PI)的相关性。 方法 收集2019年4~10月就诊患者,将46名轻度侧脑室旁LA且受教育程度大致相同的患者组成研究组,将同期50名无LA的志愿者组成对照组,收集临床资料,均行蒙特利尔认知量表(MoCA)评估、画钟测试及经颅多普勒超声检查,记录PI值。 结果 研究组MoCA评分较对照组减低(t=-3.780, P<0.001),PI值增高(t=6.875, P<0.001),且研究组MoCA分值与PI值存在显著负相关(r=-0.852, P<0.05)。研究组总体及多个认知领域分值较对照组低,其中视空间与执行、注意与计算、延迟记忆受损较对照组差异有统计学意义(P均<0.05),其与PI值呈现一定负相关(分别为r=-0.800, r=-0.386, r=-0.587, P<0.05)。画钟测试作为视空间与执行功能中一个重要组成部分,研究组评分低于对照组(t=-2.831, P<0.05),且与PI值负相关(r=-0.715, P<0.05)。 结论 轻度LA患者在亚临床期,可能已存在认知能力及脑血流储备功能受损,在LA的早期识别中PI与MoCA评估量表有等同应用价值。通过不同认知领域受损的比较,以画钟测试与PI相关性研究为例,提示临床上可在早期进行针对性干预。
中图分类号:
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