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山东大学学报(医学版)

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HDL-C和TG/HDL-C比值对山东省中老年回族人胰岛素抵抗的预测价值

王川1,侯新国1,梁凯1,闫飞1,杨俊鹏1,王令舒1,田萌1,李成乔2,张秀萍3,杨位芳4,马泽强5,陈丽1   

  1. 1.山东大学齐鲁医院内分泌科, 山东 济南 250012;  2.济宁市第二人民医院内分泌科, 山东 济宁 272049;
    3.济宁市山推社区卫生中心, 山东 济宁 272000;  4.济宁市鲁抗医院, 山东 济宁 272141; 
    5.中国重型汽车集团有限公司医院, 山东 济南 250116
  • 收稿日期:2014-02-15 出版日期:2014-05-10 发布日期:2014-05-10
  • 通讯作者: 陈丽 E-mail:chenli3@medmail.com.cn
  • 基金资助:
    “十一五”国家科技支撑计划(2009BAI80B04)

HDL-C and TG/HDL-C ratio to identify insulin resistance in middle-aged and older Hui ethnic population in Shandong Province

WANG Chuan1, HOU Xinguo1, LIANG Kai1, YAN Fei1, YANG Junpeng1, WANG Lingshu1, TIAN Meng1, LI Chengqiao2, ZHANG Xiuping3, YANG Weifang4, MA Zeqiang5, CHEN Li1   

  1. 1. Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    2. Department of Endocrinology, Second Peoples Hospital of Jining, Jining 272049, Shandong, China;
    3. Shantui Community Health Center, Jining 272000, Shandong, China;
    4. Lukang Hospital of Jining, Jining 272141, Shandong, China;
    5. China National Heavy Duty Truck Group Corporation Hospital, Jinan 250116, Shandong, China
  • Received:2014-02-15 Online:2014-05-10 Published:2014-05-10

摘要: 目的  利用临床常用的生化指标,寻找可以预测山东省中老年回族人胰岛素抵抗(IR)的替代标志物。方法  本横断面研究共入选95名男性和104名女性中老年回族人。采集患者空腹血样检测血糖、胰岛素、肝酶和血脂水平。以稳态胰岛素评价指数(HOMA-IR)评价人群IR状态,并以该指数的最高四分位数作为IR的切点,其数值为3.06。利用受试者工作特征曲线(ROC)的曲线下面积(AUC)评估潜在指标对IR的预测价值。结果  在所有研究指标中, 1/HDL-C比值 和 TG/HDL-C比值可以更好地预测人群的IR状态,其AUC值分别为0.720(95%CI:0.642~0.798)和0.710(95%CI:0.634~0.786)。1/HDL-C比值及TG/HDL-C比值预测IR的最佳切点分别为0.702(对应的HDL-C值为1.425mmol/L,敏感性为69.4%,特异性为67.3%)和1.043(敏感性为65.3%,特异性为66.7%)。结论  HDL-C和TG/HDL-C比值可以用来预测山东省中老年回族人的IR状态。

关键词: 高密度脂蛋白胆固醇, 甘油三酯/高密度脂蛋白胆固醇比值, 胰岛素抵抗;回族;山东省

Abstract: Objective  To find a surrogate marker to identify insulin resistance (IR) in middle-aged and older Hui ethnic subjects in Shandong Province of China using biochemical indicators. Methods  A total of 95 men and 104 women were included in the cross-sectional study. Fasting blood samples were collected to detect blood glucose, insulin, liver enzymes and lipid profiles. IR cut-off value was 3.06 as determined using the 75th percentile of HOMA-IR values. The areas under the curve (AUC) of the receiver operating characteristic curves (ROC) were used to compare the power of the potential markers. Results  Compared with other biochemical indicators, 1/HDL-C ratio and TG/HDL-C ratio discriminated IR much better than others, with the values of AUC being 0.720 (95% CI: 0.642-0.798) and 0.710(95% CI: 0.634-0.786),respectively. The optimal cut-off points to identify IR were 0.702 (sensitivity 69.4%, specificity 67.3%) for 1/HDL-C ratio (1.425mmol/L for HDL-C) and 1.043 (sensitivity 65.3%, specificity 66.7%) for TG/HDL-C ratio. Conclusion  HDL-C and TG/HDL-C ratio can easily identify IR in the urban middle-aged and older Hui ethnic population in Shandong Province.

Key words: Insulin resistance, Shandong Province, High-density lipoprotein cholesterol, Triglycerides/high-density lipoprotein cholesterol ratio, Hui ethnic

中图分类号: 

  • R589.2
[1] 张楠1,袁中尚2,张栩1,张祎坤1,于春晓1,高聆3,赵家军1,管庆波1,管理英4. 2型糖尿病男性患者血清睾酮与血脂关系的探讨[J]. 山东大学学报(医学版), 2014, 52(4): 58-61.
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